Evidence map›Paper›PMID 42173875›Full record

ArticleNPJ science of food2026

Faecalibacterium prausnitzii-derived extracellular vesicles ameliorate experimental colitis through regulating barrier immunity and gut microbiota.

Xinke Nie, Qiqiong Li, Ze Tao, Yushan Xu, Bingnan Li, Junhua Xie, Shaoping Nie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinke NieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Qiqiong LiState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Ze TaoState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Yushan XuState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Bingnan LiState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Junhua XieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China. junhuax@ncu.edu.cn.
Shaoping NieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China. spnie@ncu.edu.cn.

Funding

Natural Science Foundation of Jiangxi 20242BAB21031State Key Laboratory of Food Science and Resources, Nanchang University SKLF-ZZB-202543Technological Project of Jiangxi Province 20232BCD44003
6 · The paper itself

Abstract

Ulcerative colitis (UC) is closely linked to intestinal barrier dysfunction and gut dysbiosis. Bacterial extracellular vesicles (bEVs) act as key mediators of bacteria-host crosstalk, with great potential in regulating host health. Recent studies have shown that EVs derived from gut commensal bacteria offer therapeutic advantages in treating UC. Herein, we explored the therapeutic effect of Faecalibacterium prausnitzii-derived EVs (PEVs) in DSS-induced colitis mice. Results showed PEVs significantly improved intestinal barrier damage, restored Th17/Treg balance and alleviated gut dysbiosis. Further fecal microbiota transplantation (FMT) confirmed that feces from PEVs-treated mice transferred beneficial effects to recipient colitis mice. Collectively, our findings indicate that commensal gut microbiota-derived nanovesicles have the potential to serve as candidates for UC treatment.

Identifiers

PMID42173875
PMCPMC13473676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.