Evidence map›Paper›PMID 42173866›Full record

Trial reportNature communications2026

Near-infrared fluorescence imaging-guided surgery using cRGD-ZW800 to improve surgical resection margins in oral cancer: a phase I/II feasibility trial.

B E Zweedijk, L J Lauwerends, H A Galema, D J Robinson, H S de Bruijn, H Abbasi, T L March, A R P M Valentijn, M Pool, H Mast and 12 more

Registry-linked trialAbstract readClinical Trial, Phase IClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04191460 (Guided by Light), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04191460 phase2recruitingnot on this map

Guided by Light: Optimizing Surgical Excision of Oral Cancer Using Real-time Fluorescence Imaging

TypeinterventionalSponsorErasmus Medical CenterRan2022 to 2025Enrolled28ConditionsSquamous Cell Carcinoma of the Head and Neck, Oral Cancer, Squamous Cell Carcinoma of the Oral CavityArmscRGD-ZW800-1.
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

B E Zweedijk *Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0009-0000-9256-6770
L J Lauwerends *Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
H A GalemaDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
D J RobinsonDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
H S de BruijnDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
H AbbasiDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0655-7187
T L MarchDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
A R P M ValentijnDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.ORCID http://orcid.org/0009-0000-2020-9037
M PoolDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.
H MastDepartment of Oral and Maxillofacial Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0559-543X
B P JonkerDepartment of Oral and Maxillofacial Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0100-3871
J A U HardilloDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5580-5613
D MonserezDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
A SewnaikDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
S KoljenovicDepartment of Pathology, Antwerp University Hospital/ University of Antwerp, Antwerp, Belgium.
C VerhoefDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9980-8613
R J Baatenburg de JongDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
J V FrangioniCuradel Surgical Innovations, 11 Erie Drive, Natick, MA, USA.
S A KoppesDepartment of Pathology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8833-531X
D E HillingDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
A L VahrmeijerDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-9370-0011
S KeereweerDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands. s.keereweer@erasmusmc.nl.ORCID http://orcid.org/0000-0003-4665-6868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In oral squamous cell carcinoma (OSCC) surgery, inadequate tumor margins are reported in up to 85% of cases, adversely affecting outcomes. In this prospective, single-center study (n = 31; NCT04191460), we evaluated the safety and imaging feasibility of cRGD-ZW800-1, a near-infrared fluorescent integrin-targeted tracer. The secondary objective was to determine whether intraoperative fluorescence imaging could identify inadequate resection margins and inform surgical decision-making. Patients received 0.01, 0.025, or 0.05 mg/kg cRGD-ZW800-1, and tracer uptake was quantified using in vivo multi-diameter single-fiber reflectance and single-fiber fluorescence spectroscopy to optimize dosing and timing. All doses were well tolerated, achieving tumor-to-background ratios exceeding 4.5, with optimal performance at 0.025 mg/kg. Fluorescence imaging detected all 23 inadequate margins, including nine undetected by conventional assessment (sensitivity 100% versus 70%), altered surgical plans in five cases, and avoided adjuvant radiotherapy in three cases. These findings demonstrate that cRGD-ZW800-1 is safe, tumor-specific, and facilitates intraoperative margin assessment in OSCC.

Indexed as

Carcinoma, Squamous CellMargins of ExcisionMouth NeoplasmsOptical ImagingPeptides, CyclicSurgery, Computer-AssistedFeasibility StudiesFemaleFluorescent DyesHumansMaleProspective StudiesQuaternary Ammonium CompoundsSpectroscopy, Near-InfraredSulfonic Acidscyclic arginine-glycine-aspartic acid peptideFluorescent DyesPeptides, CyclicQuaternary Ammonium CompoundsSulfonic AcidsZW800-1 compound

Identifiers

PMID42173866
PMCPMC13402695

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.