Evidence map›Paper›PMID 42173849›Full record

ArticleNature communications2026

A scalable Tn5-based method for genome-wide DNA methylation profiling in development and disease.

Hanrong Hu, Nahuel Simonet, Ece Naz Bilgiç, Heather Murray, Regina Reimann, Markus Rechsteiner, Fides Zenk

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hanrong Hu *Ecole Polytechnique Federale de Lausanne (EPFL), School of Life Sciences, Brain Mind Institute, EpiGN-NeuroNA Chair in Epigenomics of Neurodevelopmental Disorders, Station 19, Lausanne, Switzerland.ORCID http://orcid.org/0009-0007-7020-5799
Nahuel Simonet *Ecole Polytechnique Federale de Lausanne (EPFL), School of Life Sciences, Brain Mind Institute, EpiGN-NeuroNA Chair in Epigenomics of Neurodevelopmental Disorders, Station 19, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8125-5870
Ece Naz BilgiçEcole Polytechnique Federale de Lausanne (EPFL), School of Life Sciences, Brain Mind Institute, EpiGN-NeuroNA Chair in Epigenomics of Neurodevelopmental Disorders, Station 19, Lausanne, Switzerland.ORCID http://orcid.org/0009-0003-7211-8593
Heather MurrayEcole Polytechnique Federale de Lausanne (EPFL), School of Life Sciences, Brain Mind Institute, EpiGN-NeuroNA Chair in Epigenomics of Neurodevelopmental Disorders, Station 19, Lausanne, Switzerland.
Regina ReimannUniversitätsSpital Zürich, Schmelzbergstrasse 12, Zürich, Switzerland.
Markus RechsteinerUniversitätsSpital Zürich, Schmelzbergstrasse 12, Zürich, Switzerland.
Fides ZenkEcole Polytechnique Federale de Lausanne (EPFL), School of Life Sciences, Brain Mind Institute, EpiGN-NeuroNA Chair in Epigenomics of Neurodevelopmental Disorders, Station 19, Lausanne, Switzerland. fides.zenk@epfl.ch.ORCID http://orcid.org/0000-0002-0324-0902

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 218299
6 · The paper itself

Abstract

DNA methylation is a key epigenetic modification involved in development and disease, including cancer, and serves as a biomarker for diagnosis. Current detection methods, such as bisulfite sequencing, provide base-pair resolution but require high sequencing depth and cost. Here, we developed C

Indexed as

DNA MethylationAnimalsBrain NeoplasmsEpigenesis, GeneticHigh-Throughput Nucleotide SequencingHumansSequence Analysis, DNAZebrafish

Identifiers

PMID42173849
PMCPMC13385352

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.