ArticleTranslational psychiatry2026
Lonely minds, inflamed guts: metabolic and circulating protein pathways linking social isolation and loneliness to inflammatory bowel disease.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Mounting evidence suggests that psychosocial stressors, such as social isolation and loneliness, contribute to gastrointestinal disorders by disrupting gut-brain interactions. We aim to investigate the associations of social isolation, loneliness, and their related alterations in metabolism and circulating proteins with the risk of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). 275,157 adults from the UK Biobank were analyzed, including metabolomic data from 68,362 participants and proteomic profiling from 29,339 participants. The exposures included social isolation, loneliness, and their related metabolites and circulating proteins, with incident IBD as the outcome. Cox regression and two-sample Mendelian randomization (TSMR) analysis were utilized to examine the associations. Over a mean follow-up of 13.49 years, this cohort study identified 1565 incident IBD cases, comprising 1063 UC cases and 492 CD cases. Social isolation and loneliness showed significant associations with an elevated risk of IBD (social isolation: hazard ratio [HR]
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