Evidence map›Paper›PMID 42173832›Full record

ArticleNature communications2026

Genetic variants affect diurnal glucose levels throughout the day.

Nasa Sinnott-Armstrong, Satu Strausz, Lea Urpa, Erik Abner, Josephine P Johnson, Jesse Valliere, Teele Palumaa, FinnGen, Estonian Biobank Research Team, VA Million Veteran Program and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Nasa Sinnott-ArmstrongHerbold Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA. nasa@fredhutch.org.ORCID http://orcid.org/0000-0003-4490-0601
Satu Strausz *Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-6778-4848
Lea Urpa *Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-8712-3518
Erik AbnerEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-6529-3161
Josephine P JohnsonCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Jesse ValliereBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Teele PalumaaEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-4258-3294
FinnGen
Estonian Biobank Research Team
VA Million Veteran Program
Priit PaltaEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-9320-7008
Hassan S DashtiBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Kyong-Mi ChangCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6811-9364
Marijana VujkovicCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4924-5714
Mark DalyInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0949-8752
Jonathan K PritchardBrotman Baty Institute, University of Washington, Seattle, USA.ORCID http://orcid.org/0000-0002-8828-5236
Richa SaxenaBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2233-1065
Samuel E JonesInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. samuel.jones@helsinki.fi.ORCID http://orcid.org/0000-0003-0153-922X
Hanna M OllilaInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. hanna.m.ollila@helsinki.fi.ORCID http://orcid.org/0000-0002-5302-6429

Funding

Genetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0M
An integrative omics approach to investigate gene-environment interaction in colorectal cancer riskR01CA273198 · NCI · FRED HUTCHINSON CANCER CENTER · PI William JAMES GAUDERMAN, ULRIKE PETERS · 2023 to 2026
$3.5M
Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders.R01HG012810 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel J Gottlieb · 2023 to 2026
$2.6M
A genomics-based strategy to precision phenotyping and drug repositioning in cardiometabolic diseasesR01DK134575 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Marijana Vujkovic · 2023 to 2026
$1.4M
The impact of overnight nutrition support on sleep and circadian rhythm disruption in the ICUR00HL153795 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DASHTI, HASSAN S. · 2023 to 2025
$747k
BLRD VA I01 BX003362NCI NIH HHS R01 CA273198NHGRI NIH HHS R01 HG012810NHLBI NIH HHS R00 HL153795NIDDK NIH HHS R01 DK107859NIDDK NIH HHS R01 DK134575Wellcome Trust
6 · The paper itself

Abstract

Circadian rhythms not only coordinate the timing of wake and sleep but also regulate homeostasis within the body, including glucose metabolism. The genetic variants that contribute to the temporal control of glucose levels have not been previously examined. Using genome-wide data from ~420,000 individuals from the UK Biobank and replication in ~100,000 individuals from the Estonian Biobank, ~500,000 from FinnGen, ~160,000 from the VA Million Veteran Program, and ~52,000 from the MGB Biobank, we show that glucose levels are under diurnal genetic control. We discover a robust temporal association of glucose levels at the Melatonin receptor 1B (MTNR1B, rs10830963, P = 1×10

Indexed as

Blood GlucoseCircadian RhythmCryptochromesGenetic VariationGlucoseReceptor, Melatonin, MT2Diabetes Mellitus, Type 2FemaleGenome-Wide Association StudyHumansMelatoninPolymorphism, Single NucleotideSleepBlood GlucoseCRY2 protein, humanCryptochromesGlucoseMelatoninMTNR1B protein, humanReceptor, Melatonin, MT2

Identifiers

PMID42173832
PMCPMC13385737

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.