ReviewChemical reviews2026
Membrane-Spanning Nanopores Formed from Nucleic Acids.
Review in Chemical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Programmed membrane breaching with nanosyringes unlocks control over biochemical responses in synthetic cells.Nature nanotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane-spanning nanopores have emerged as powerful tools in a wide range of technological applications, particularly in single-molecule sensing. This review explores recent advancements in creating synthetic, membrane-spanning nanopores constructed from nucleic acids, focusing on DNA nanopores. These self-assembled nanochannels offer a highly programmable and versatile alternative to traditional protein-based nanopores. We summarize the rational design principles and examine advantages and disadvantages of diverse architectures ranging from subnanometer channels for selective ion translocation to customizable geometries for the transport of macromolecules. Key aspects of this emerging field are discussed, including methods for membrane anchoring, the influence of lipid rearrangements on ionic conductance, and the dynamic control of nanopore function. Nucleic acid nanopores are further highlighted as functional components for synthetic cell signaling, single-molecule detection, and cellular manipulation. This review concludes with an outlook on the field, focusing in particular on the unique opportunities of RNA origami for creating genetically encodable nanopores for bottom-up synthetic biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.