ArticleContemporary clinical trials2026
Rationale and study protocol for a randomized controlled MIND diet feeding trial for breast cancer-related cognitive impairment.
Article in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07018986 (The MIND-BC Study), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The MIND-BC Study: MIND Diet for Breast Cancer Cognition
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13 authors.
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Abstract
backgroundDespite well-documented cancer-related cognitive impairment (CRCI) burden, few efficacious interventions exist to mitigate CRCI. Biological mechanisms include inflammation and oxidative stress, which may be influenced by diet. Dietary interventions could be highly disseminable and acceptable, but have not been evaluated for CRCI. This study will examine the efficacy of a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on CRCI.
methodsBreast cancer survivors will be eligible if they have completed adjuvant treatment 6 months to three years previously, self-reported CRCI, and low adherence to the MIND diet. Participants (N = 200) will be randomized 1:1 to a 12-week feeding trial of the MIND diet versus their usual diet. To achieve maximal effect, the study consists of two 12-week phases: 1) intervention phase, MIND diet meals will be provided with skill coaching, and 2) maintenance phase, determine the extent of the diet in maintaining cognition to determine efficacy and future scalability. Subjective cognition will be evaluated as the primary outcome. Secondary outcomes include objective CRCI, self-reported fatigue, mood, and quality of life. Assessments will occur immediately before the intervention (baseline), at the end of the intervention phase (first 12-week phase), and end of the maintenance phase (second 12-week phase). DISCUSSION: Findings will describe the relationship between diet and CRCI and provide a novel examination of the MIND diet as a strategy to mitigate CRCI. Results have potential to influence clinical practice, translational research, and public health efforts aimed at developing medical nutrition therapy guidelines tailored to this population.
trial registrationThis study was registered on ClinicalTrials.gov, identifier NCT07018986, on 2025-06-13.
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