LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation.

Yang Xu, Sujith Rajan, Colin K L Phoon, Mindong Ren, M Mahmood Hussain, Michael Schlame

Abstract read

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Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Yang XuDepartment of Anesthesiology, New York University Langone Medical Center, New York, NY, USA.

Sujith RajanDepartment of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, USA.

Colin K L PhoonDepartment of Pediatrics, New York University Langone Medical Center, New York, NY, USA.

Mindong RenDepartment of Anesthesiology, New York University Langone Medical Center, New York, NY, USA.

M Mahmood HussainDepartment of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, USA.

Michael SchlameDepartment of Anesthesiology, New York University Langone Medical Center, New York, NY, USA. Electronic address: Michael.schlame@med.nyu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysosomal phospholipid degradation produces two types of metabolites, either 2-lysophospholipids with saturated fatty acids in sn-1 position or 1-lysophospholipids with unsaturated fatty acids in sn-2 position. They may either be degraded further or reused for phospholipid synthesis. We found that LPLAT7 (LPGAT1), an acyltransferase of the endoplasmic reticulum, reacylates specifically lysosome-derived 1-lysophospholipids that carry an unsaturated chain. The enzymatic activity of LPLAT7 was specific for stearoyl-CoA and 1-lyso-2-acyl positional isomers of unsaturated lysophospholipids. In Huh7 cells, Lplat7 knockout prevented the reacylation of 1-lysophospholipids generated by the lysosomal degradation of exogenous

Indexed as

AcyltransferasesLysophospholipidsLysosomesPhospholipidsAnimalsHumansMiceAcyltransferasesLysophospholipidsPhospholipidslipidomicslysophospholipidphospholipase Aphospholipid/biosynthesisphospholipid/metabolism

Identifiers

PMID42173283

DOI10.1016/j.jlr.2026.101064

PMCPMC13277423

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