Evidence map›Paper›PMID 42172440›Full record

ArticleAging2026

Transcriptional programs diverge in aging mouse and human skeletal muscle.

Charles D Hwang, Siti Rahmayanti, Yori Endo, Seamus P Caragher, Luisa Weber, Jessica Mroueh, Simone Marini, Indranil Sinha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charles D Hwang *Division of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.
Siti Rahmayanti *Division of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.
Yori EndoDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.
Seamus P CaragherDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.
Luisa WeberDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.
Jessica MrouehDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.
Simone MariniDepartment of Epidemiology, University of Florida College of Public Health and Health Professions, Gainesville, FL 32611, USA.
Indranil SinhaDivision of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA 02115, USA.

Funding

PHD2 mediated loss of hypoxia signaling limits skeletal muscle regeneration and exercise response in agingR01AG078307 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Indranil Sinha · 2023 to 2026
$1.6M
NIA NIH HHS R01 AG078307
6 · The paper itself

Abstract

Animal models provide a crucial scientific substrate for medical innovation, yet findings in these models do not always translate directly to humans. Although murine models are extensively employed to study skeletal muscle aging, the extent to which they diverge from the human aging process remains poorly understood. This study examined transcriptional changes with aging in mouse and human skeletal muscle. RNA bulk-sequencing was performed on gastrocnemius muscles from young and old C57BL/6 mice and compared to transcriptomic data from young and old healthy human vastus lateralis muscles obtained from the GESTALT study (NIA/NIH) via the Gene Expression Omnibus database. Cross-species comparison revealed substantial divergence in age-associated transcriptional profiles, with fewer than 5% of significant GO and KEGG terms shared between species. Hypoxia signaling, VEGFA, and inflammatory pathways showed concordant downregulation with aging in both species; however, angiogenesis, neurogenesis, and myogenesis demonstrated opposing or non-significant trends. These findings caution against direct extrapolation of murine aging transcriptomics to human skeletal muscle biology, though select conserved pathways may represent viable cross-species targets for future investigation.

Indexed as

AgingMuscle, SkeletalTranscriptomeAgedAnimalsHumansMaleMiceMice, Inbred C57BLNeovascularization, Physiologicagingangiogenesishypoxiaregenerationskeletal muscle

Identifiers

PMID42172440
PMCPMC13632859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.