Evidence map›Paper›PMID 42172334›Full record

ArticleScience advances2026

Bandgap-enabled ultrasound tissue marking by a biodegradable metastructured hydrogel implant.

Zhangqi Pan, Lejie Qin, Bo Gao, Na Li, Yizhou Huang, Yuchen Zhou, Mengyuan Zhou, Yibo Huang, Jie Chen, Wei Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhangqi PanSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0000-3417-308X
Lejie QinSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0006-1050-0916
Bo GaoSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0003-0806-5629
Na LiSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0001-9417-3521
Yizhou HuangSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0009-9654-9674
Yuchen ZhouSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Mengyuan ZhouSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Yibo HuangSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Jie ChenSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Wei WangSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Yue LianSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0009-7810-1411
Zeqing CaiSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0004-6647-4134
Hanchuan TangSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-8494-9031
Jianfeng ZangSchool of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-1775-4605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implantation of tissue markers within lesions is standard practice in breast cancer diagnosis and treatment, which provides critical guidance for regular follow-up and precise surgical localization. However, the identification of existing markers is limited by nonspecificity and low resolution of conventional ultrasound imaging. The use of rigid materials to compensate for this constraint has resulted in inadequate biodegradability and biocompatibility. Here, we propose a biodegradable metastructured hydrogel tissue marker with acoustic bandgaps enabling specific ultrasonic reflection spectra. Through frequency-to-color mapping on B-mode images, visualization is achieved, with scalable designs allowing multiple marker distinction. Deliverable via an 18-gauge puncture needle and featuring tissue-mimicking softness, the metagel marker mitigates displacement risks, tissue damage, and inflammation. Live pig experiments demonstrate clear identification and dynamic stability. Six-week rat studies confirm long-term marking ability and biocompatibility. These results support the metagel marker's clinical potential for breast cancer management and precise therapy.

Indexed as

Absorbable ImplantsBiocompatible MaterialsBreast NeoplasmsHydrogelsAnimalsFemaleHumansRatsSwineUltrasonographyBiocompatible MaterialsHydrogels

Identifiers

PMID42172334
PMCPMC13196780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.