Evidence map›Paper›PMID 42172329›Full record

ArticleScience advances2026

Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress.

Michael C Mazzola, Ting Zhao, Anna Kiem, Trine A Kristiansen, Karin Gustafsson, Lai Ping Wong, Emily Scott-Solomon, Marissa D Fahlberg, Christina Mayerhofer, Ernst Mayerhofer and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Michael C MazzolaCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-3000-7997
Ting ZhaoCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Anna KiemCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Trine A KristiansenCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Karin GustafssonCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Emily Scott-SolomonHarvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Marissa D FahlbergLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.ORCID 0000-0002-2597-7147
Christina MayerhoferCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-5755-1458
Ernst MayerhoferCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8902-4209
Sarah ForwardLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.
Emane Rose AssitaLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.
Giulia SchiroliCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-9812-8728
Maris HandleyCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Youmna KfouryCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Tsuyoshi FukushimaCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Dan LiCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-6332-1093
Samuel KeyesCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Azeem ShardaCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Jelena MilosevicCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0001-7062-2276
Hiroki KatoCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-4021-3356
Pavel IvanovDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
David B SykesCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-9788-0221
Sheldon J J KwokLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.ORCID 0000-0001-7880-0401
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0002-4240-5466
Vijay G SankaranHarvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.ORCID 0000-0003-0044-443X
Ya-Chieh HsuHarvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.ORCID 0000-0002-0178-7373
David T ScaddenCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID 0000-0001-9821-7133

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6M
Cyclic Flow Cytometry for Ultra-High Marker Single-Cell AnalysisR44GM139504 · NIGMS · LASE INNOVATION INC. · PI KWOK, SHELDON J.J. · 2021 to 2022
$1.7M
NIDDK NIH HHS P30 DK040561NIGMS NIH HHS R44 GM139504
6 · The paper itself

Abstract

Cell stress can increase the use of methylated guanosine (m

Indexed as

Caloric RestrictionGuanosineHematopoiesisHematopoietic Stem CellsHeterogeneous-Nuclear RibonucleoproteinsInternal Ribosome Entry SitesPolypyrimidine Tract-Binding ProteinRNA CapsStress, PhysiologicalAnimalsCell LineageGenes, ReporterHomeostasisMaleMice, Inbred C57BLPeptide Chain Initiation, Translational7-methylguanosineGuanosineHeterogeneous-Nuclear RibonucleoproteinsInternal Ribosome Entry SitesPolypyrimidine Tract-Binding ProteinPtbp1 protein, mouseRNA Caps

Identifiers

PMID42172329
PMCPMC13196779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.