Evidence map›Paper›PMID 42172323›Full record

ArticleScience advances2026

Evolution of a central dopamine circuit underlies adaptation of a light-evoked sensorimotor response in the blind cavefish.

Robert A Kozol, Ally Canavan, Bernadeth Tolentino, Alex C Keene, Johanna E Kowalko, Erik R Duboué

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Robert A KozolWilkes Honors College, Florida Atlantic University, Jupiter, FL, USA.ORCID 0000-0001-5320-1453
Ally CanavanWilkes Honors College, Florida Atlantic University, Jupiter, FL, USA.
Bernadeth TolentinoWilkes Honors College, Florida Atlantic University, Jupiter, FL, USA.ORCID 0009-0002-9467-2862
Alex C KeeneDepartment of Biology, Texas A&M University, College Station, TX, USA.ORCID 0000-0001-6118-5537
Johanna E KowalkoDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, USA.
Erik R DubouéWilkes Honors College, Florida Atlantic University, Jupiter, FL, USA.ORCID 0000-0003-3303-5149

Funding

A genomic toolkit for functional interrogation of trait variation in an aquatic modelR24OD030214 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI KEENE, ALEX C, WARREN, WESLEY CHARLES · 2022 to 2025
$2.8M
Evolutionary approaches to identify genetic architecture regulating aggressionR35GM138345 · NIGMS · LEHIGH UNIVERSITY · PI KOWALKO, JOHANNA E. · 2020 to 2024
$2.0M
Understanding complex trait architecture through population genomicsR01GM127872 · NIGMS · UNIVERSITY OF MINNESOTA · PI KEENE, ALEX C, MCGAUGH, SUZANNE · 2018 to 2021
$1.7M
The relationship between eye morphogenesis and brain developmentR15HD099022 · NICHD · LEHIGH UNIVERSITY · PI KOWALKO, JOHANNA E. · 2020 to 2020
$463k
Determining the impact of early adversity on the developing vertebrate brainR15MH132057 · NIMH · FLORIDA ATLANTIC UNIVERSITY · PI DUBOUE, ERIK ROLANDO · 2022 to 2022
$458k
Functional dissection of brain-wide circuits modulating recovery from stress.R15MH118625 · NIMH · FLORIDA ATLANTIC UNIVERSITY · PI DUBOUE, ERIK ROLANDO · 2018 to 2018
$446k
A Screen for Identifying Insomnia Genes.R21NS122166 · NINDS · TEXAS A&M UNIVERSITY · PI KEENE, ALEX C, KOWALKO, JOHANNA E. · 2021 to 2021
$409k
NICHD NIH HHS R15 HD099022NIGMS NIH HHS R01 GM127872NIGMS NIH HHS R35 GM138345NIH HHS R24 OD030214NIMH NIH HHS R15 MH118625NIMH NIH HHS R15 MH132057NINDS NIH HHS R21 NS122166
6 · The paper itself

Abstract

Adaptive behaviors emerge in novel environments through functional changes in neural circuits. While relationships between circuit function and behavior are well studied, how evolution shapes circuits to drive behavioral adaptation is poorly understood. The Mexican cavefish,

Indexed as

Adaptation, PhysiologicalBiological EvolutionBlindnessCharacidaeDopamineAnimalsBrainLightDopamine

Identifiers

PMID42172323
PMCPMC13196759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.