Evidence map›Paper›PMID 42172282›Full record

ArticlePloS one2026

Timely Integration of specialist palliative care into oncology care for patients receiving radiotherapy for bone metastases: A study procotol for the TIPZO-RT Randomized Controlled Trial.

Anouk van Oss, Joanne M van der Velden, Helena M Verkooijen, Rebecca van Jaarsveld, Ginette M Hesselmann, Evelien J M Kuip, Paulien G Westhoff, Natasja J H Raijmakers, Yvette M van der Linden, Roxanne Gal

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06805396 (Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06805396 phase2recruitingnot on this map

Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial (TIPZO-RT Trial)

TypeinterventionalSponsorRoxanne GalRan2025 to 2027Enrolled246ConditionsBone Metastases in Subjects With Advanced Cancer, RadiotherapyArmsPalliative Care Consult
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anouk van OssCenter of Expertise in Palliative Care, Leiden University Medical Center, Leiden, The Netherlands.
Joanne M van der VeldenDepartment of Radiotherapy, Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Helena M VerkooijenDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Rebecca van JaarsveldCenter of Expertise in Palliative Care, Leiden University Medical Center, Leiden, The Netherlands.
Ginette M HesselmannDivision of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands.
Evelien J M KuipDepartment of Medical Oncology and Department of Anaesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Paulien G WesthoffDepartment of Radiotherapy, Radboud University Medical Center, Nijmegen, The Netherlands.
Natasja J H RaijmakersNetherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
Yvette M van der LindenCenter of Expertise in Palliative Care, Leiden University Medical Center, Leiden, The Netherlands.
Roxanne GalDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-7340-4581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients living with advanced cancer often benefit from palliative care. Timely referral to specialist palliative care improves quality of life and reduces potentially inappropriate end-of-life care. Despite these benefits, specialist palliative care is frequently introduced late and inconsistently. This study evaluates whether systematically offering a consultation with the hospital palliative care consultation team (PCCT) to all patients referred for radiotherapy for symptomatic bone metastases improves satisfaction with care. PATIENTS AND

methodsThe Timely Integration of Palliative Care in Oncology care for patients referred for palliative RadioTherapy (TIPZO-RT) trial follows the Trials within Cohorts design and is embedded within the PRospective Evaluation of interventional StudiEs on boNe meTastases (PRESENT+) cohort. Following cohort enrollment, 246 patients will be randomized (1:1) to either the intervention or control group. Patients in the intervention group are offered a PCCT consultation, which they may accept or refrain from. Patients in the control group are not informed about the trial and continue to receive usual care. After four weeks, patient satisfaction with care (affective behavior, EORTC Satisfaction with Cancer Care core questionnaire (EORTC PATSAT-C33)) will be compared between the groups. Secondary outcomes include symptom burden, quality of life, overall survival, and palliative care utilization. Additionally, in the intervention group, patients' experiences with the consultation are evaluated. DISCUSSION: Integrating palliative care into oncological care for patients with advanced cancer is essential to deliver comprehensive, patient-centered care that addresses physical, psychosocial and spiritual needs. This pragmatic study may provide evidence to support timely integration of specialist palliative care for all patients with bone metastases who may benefit from specialist palliative care. Using the Trials within Cohorts design, this study generates real-world evidence on the acceptance or need for a consultation with the PCCT, while minimizing disappointment or response bias, as patients in the control group are not informed.

trial registrationClinicalTrials.gov ID NCT06805396. Registered on 25-03-2025.

Indexed as

Bone NeoplasmsPalliative CareClinical Trials, Phase II as TopicFemaleHumansMalePatient SatisfactionProspective StudiesQuality of LifeRandomized Controlled Trials as TopicReferral and Consultation

Identifiers

PMID42172282
PMCPMC13196936

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.