Evidence map›Paper›PMID 42171888›Full record

ArticleDigestive diseases and sciences2026

Psoas Muscle Trajectory and Survival After Liver Transplantation for Steatotic Liver Disease in Severe Obesity.

Baila Elkin, Mohammad Alabbas, Qijun Yang, Blake Brandon, Christopher Coppa, Manal Abdelmalek, Omar T Sims, Jamile Wakim-Fleming

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Baila ElkinDepartment of Gastroenterology and Hepatology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Mohammad AlabbasDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA. alabbam@ccf.org.
Qijun YangDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Blake BrandonDepartment of Radiology, Cleveland Clinic, Cleveland, OH, USA.
Christopher CoppaDepartment of Radiology, Cleveland Clinic, Cleveland, OH, USA.
Manal AbdelmalekDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Omar T SimsDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.
Jamile Wakim-FlemingDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia after liver transplantation is poorly characterized in recipients with metabolic dysfunction-associated steatotic liver disease (MASLD) and severe obesity. We evaluated longitudinal changes in psoas muscle index (PMI) after transplantation and examined whether PMI trajectory was associated with post-transplant survival.

methodsWe performed a retrospective single-center study of adults with MASLD and body mass index ≥ 35 kg/m

resultsSeventy-three recipients were included; mean age was 59.3 years, 50.7% were women, median body mass index was 38.1 kg/m2, and mean Model for End-Stage Liver Disease score was 23.6. PMI declined significantly from baseline to 6 months (β =  - 0.60, 95% confidence interval [CI] - 0.98 to - 0.22; p = 0.002) and 1 year (β =  - 0.46, 95% CI - 0.83 to - 0.09; p = 0.015), with persistent reduction at 3 years. Survivors showed modest early decline followed by relative stabilization, whereas non-survivors demonstrated steeper decline. However, pre-transplant PMI, 6-month PMI, and early PMI change were not significantly associated with mortality.

conclusionsIn liver transplant recipients with MASLD and severe obesity, muscle loss worsens during the first post-transplant year and may persist thereafter. These findings raise questions regarding optimal timing of nutritional and physical rehabilitation and justify larger studies to determine the prognostic significance of post-transplant muscle trajectories.

Indexed as

Fatty LiverLiver TransplantationObesity, MorbidPsoas MusclesSarcopeniaAgedBody Mass IndexEnd Stage Liver DiseaseFemaleHumansMaleMiddle AgedRetrospective StudiesBody compositionComputed tomographyFrailtyGraft outcomesMetabolic syndromeMortality riskMuscle wastingMyosteatosisRehabilitationTransplant recipient

Identifiers

PMID42171888
PMCPMC13558451

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