Evidence map›Paper›PMID 42171790›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2026

Reduction in utilization of radiation for heterotopic ossification prophylaxis following acetabular surgery during the COVID-19 pandemic.

Johnathan W Riley, Isaac J Spears Iii, Rowdy C Lee, Julian C Clark Ii, Cole Debevec, Josny Thimothee, Scott Weathersby, Priyanka V Nehete, Peter N Mittwede, Patrick F Bergin

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Johnathan W RileyDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA. jriley5@umc.edu.
Isaac J Spears IiiSchool of Medicine, University of Mississippi Medical Center, Jackson, USA.
Rowdy C LeeDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA.
Julian C Clark IiDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA.
Cole DebevecDepartment of Orthopaedics, Louisiana State University Health Sciences Center Shreveport, Shreveport, USA.
Josny ThimotheeDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA.
Scott WeathersbyDepartment of Emergency Medicine, Baylor Scott & White Medical Center - Temple, Temple, USA.
Priyanka V NeheteDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA.
Peter N MittwedeDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA.
Patrick F BerginDepartment of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHeterotopic ossification (HO) is common following acetabular surgery. Evidence comparing external beam radiation (XRT) and nonsteroidal anti-inflammatory drugs (NSAIDs) for HO prophylaxis remains conflicting. This study evaluated changes in XRT utilization during the COVID-19 pandemic and compared the efficacy of XRT versus NSAIDs.

methodsA retrospective review was conducted of 180 patients undergoing open acetabular fracture fixation at a level 1 trauma center from 2018 to 2021. High-risk patients received XRT or indomethacin if XRT was declined. Outcomes included prophylaxis method, severe (Brooker 3 or 4) HO, and HO resection.

resultsXRT utilization decreased significantly during the pandemic (74.3% vs. 28.0%, P < 0.001). While severe HO rates remained similar (7.1% with XRT and 9.9% with NSAIDs) (P = 0.498), the only three HO resections were in the NSAIDs cohort.

conclusionDespite reduced XRT use during COVID-19, HO outcomes were unchanged, suggesting both XRT and NSAIDs are effective prophylaxis options.

Indexed as

AcetabulumCOVID-19Fractures, BoneOssification, HeterotopicPostoperative ComplicationsAdultAgedAnti-Inflammatory Agents, Non-SteroidalFemaleHumansIndomethacinMaleMiddle AgedRetrospective StudiesSARS-CoV-2Anti-Inflammatory Agents, Non-SteroidalIndomethacinCOVID-19External beam radiationHeterotopic ossificationPandemicProphylaxis

Identifiers

PMID42171790
PMCPMC13197439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.