Evidence map›Paper›PMID 42171765›Full record

ArticleApplied microbiology and biotechnology2026

Characterization and evaluation of a novel polylactic acid-made bioreactor for large-scale adherent cell expansion.

Björn Boshof, Alena Hüppner, Johanna Eichberg, Henning Reyer, Lukas Käßer, Anne Kölsch

Abstract read
In one paragraph

Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Björn Boshof *Green Elephant Biotech GmbH, Giessen, Germany. bjoern@greenebt.com.ORCID http://orcid.org/0009-0009-7559-023X
Alena Hüppner *TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.
Johanna EichbergGreen Elephant Biotech GmbH, Giessen, Germany.ORCID http://orcid.org/0009-0000-3172-1036
Henning ReyerGreen Elephant Biotech GmbH, Giessen, Germany.ORCID http://orcid.org/0009-0007-2838-069X
Lukas KäßerGreen Elephant Biotech GmbH, Giessen, Germany.
Anne KölschTRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany. Anne.Koelsch@trOn-Mainz.de.

Funding

German Research Allowance (Forschungszulage) under the Act on Tax Incentives for Research and Development (Forschungszulagengesetz - FZulG) [BSFZ certificate no. 168-337-828/2023-1]German Research Allowance (Forschungszulage) under the Act on Tax Incentives for Research and Development (Forschungszulagengesetz - FZulG) [BSFZ certificate no. 168-337-828/2026-1]LOEWE - Landes-Offensive zur Entwicklung Wissenschaftlich-ökonomischer Exzellenz, Förderlinie 3: KMU-Verbundvorhaben (State Offensive for the Development of Scientific and Economic Excellence) [project no. 2132/25-241]
6 · The paper itself

Abstract

Efficient large-scale expansion of adherent mammalian cells is essential for the production of recombinant proteins, viral vectors, and vaccines. Conventional multilayer flasks rely on scale-out approaches, require extensive manual handling, and lack monitoring process control compared to bioreactors. Here, we evaluate the CellScrew®, a dynamic 2D culture system available in three sizes ranging from 851 to 10,197 cm

Indexed as

BioreactorsCell Culture TechniquesPolyestersAnimalsCell AdhesionCell Line, TumorCell ProliferationCell SurvivalGlucoseHEK293 CellsHumansMiceOxygenGlucoseOxygenPolyesterspoly(lactide)B16-F10 cellsCT-26 WT cellsHEK-293 cellsLarge-scale cell culturePolylactic acidSustainable bioprocessing

Identifiers

PMID42171765
PMCPMC13197453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.