ArticleInternational journal of colorectal disease2026
Automated deep learning model for predicting pathological complete response in rectal cancer: A tool to organ-preserving strategies.
Article in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccurate identification of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) remains a key clinical challenge. Clinical complete response is an imperfect surrogate, and pCR can only be definitively established after surgery. We developed a fully automated, segmentation-free deep learning model to support post-treatment response assessment using routine T2-weighted MRI.
methodsA longitudinal three-dimensional (3D) siamese convolutional neural network was trained using paired pre- and post-nCRT axial T2-weighted MRI volumes and a normalized signed voxel-wise difference map. The multitask framework simultaneously predicted rectal wall response (good response: modified Ryan score 0-1 vs poor response ≥ 2) and nodal status (ypN0 vs ypN +), from which pCR probability (ypT0N0) was derived. A retrospective single-center cohort of 195 patients was divided into training and independent test sets stratified by pCR status. Performance was evaluated using AUC-ROC and standard classification metrics with bootstrap-derived 95% confidence intervals.
resultsIn the independent test set (n = 49; pCR prevalence 18.5%), the model achieved an AUC-ROC of 0.71 (95% CI: 0.55-0.85) for pCR prediction. At the selected operating threshold, sensitivity was 100% (95% CI: 70.1-100) and negative predictive value (NPV) was 100% (95% CI: 81.6-100), with a specificity of 42.5% (95% CI: 28.5-57.8). The high NPV reflects the low prevalence of pCR in the study cohort and may vary across external populations.
conclusionsThis fully automated longitudinal deep learning model demonstrated moderate discrimination and a high-sensitivity profile for pCR detection. Its performance suggests potential utility as a screening or triage tool to support multidisciplinary assessment, rather than to directly guide organ-preserving strategies. External multicenter validation is required before clinical implementation.
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