Evidence map›Paper›PMID 42171732›Full record

ArticleRadiation and environmental biophysics2026

Temporal and spatial patterns of γH2AX signaling in different human cells after exposure to X-rays and UV-C light.

Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Alice Mentana, Daniele Parodi, Giulia Peterlin, Rossella Semerano, Cecilia Riani, Andrea Previtali, Anna Tricarico and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation and environmental biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Isabella GuardamagnaLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Leonardo LonatiLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy. leonardo.lonati@unipv.it.
Ombretta IariaLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Alice MentanaLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Daniele ParodiLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Giulia PeterlinLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Rossella SemeranoLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Cecilia RianiLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.
Andrea PrevitaliUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100, Pavia, Italy.
Anna TricaricoUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100, Pavia, Italy.
Paola Tabarelli de FatisUnit of Medical Physics, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy.
Giovanni Battista IvaldiUnit of Radiation Oncology, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy.
Paola PeruccaUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100, Pavia, Italy.
Ornella CazzaliniUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100, Pavia, Italy.
Giorgio BaioccoLaboratory of Radiation Biophysics and Radiobiology, A. Volta, Department of Physics, University of Pavia, 27100, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phosphorylation of H2AX at serine 139 (γH2AX) is a marker of DNA damage response, well characterized after ionizing radiation (IR) exposure. In this work we compared γH2AX activation in different human cell lines exposed to X-rays, up to 5 Gy, or UV-C light (below ionization threshold), up to 40 J/m

Indexed as

HistonesSignal TransductionUltraviolet RaysCell LineDNA DamageDose-Response Relationship, RadiationHumansPhosphorylationTime FactorsX-RaysH2AX protein, humanHistonesDNA damage responseUltraviolet and ionizing radiationUV-CγH2AX

Identifiers

PMID42171732
PMCPMC13303546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.