Evidence map›Paper›PMID 42171731›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Anna-Maria Spektor, Sergio Armando Zapata Bonilla, Philipp Mildenberger, Anton Kilburg, Daniela Driess, Erik Winter, Michael Kloth, Mathias Schreckenberger, Tobias Bäuerle, Thomas Kindler and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anna-Maria SpektorDepartment of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany, Germany.ORCID 0009-0005-1092-5773
Sergio Armando Zapata BonillaUniversity Cancer Center, University Medical Center, Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany. Sergio.ZapataBonilla@unimedizin-mainz.de.ORCID 0000-0002-0193-6201
Philipp MildenbergerInstitute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University Mainz, Mainz, Germany.
Anton KilburgDepartment of Diagnostic and Interventional Radiology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.
Daniela DriessDepartment of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany, Germany.
Erik WinterDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Michael KlothDepartment of Pathology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.
Mathias SchreckenbergerDepartment of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany, Germany.
Tobias BäuerleDepartment of Diagnostic and Interventional Radiology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.
Thomas KindlerUniversity Cancer Center, University Medical Center, Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany.
Uwe HaberkornDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Maria PouyiourouClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Alwin KrämerClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Tilmann BochtlerClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Manuel RöhrichDepartment of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOncological treatment in a substantial portion of patients with cancer of unknown primary (CUP) remains challenging due to limitations of conventional imaging and positron emission tomography/computed tomography with

methods13 patients with extra-cervical CUP underwent both

results21 metastases of 3 patients with single-site and 6 patients with oligometastasized CUP were analyzed. 4 patients with previously extirpated metastases showed no uptake. No increased detection rate of primary tumors could be observed by either tracer. Differences of TBRmax in all metastatic sites and of TTRmax in organ metastases were significant.

conclusionDue to higher tissue contrast in organs, our findings suggest that

Indexed as

Fibroblast Activation Protein AlphaFluorodeoxyglucose F18Neoplasms, Unknown PrimaryPositron Emission Tomography Computed TomographyRadiopharmaceuticalsAgedFemaleGallium RadioisotopesHumansMaleMiddle AgedQuinolinesRetrospective Studies68Ga-FAPIFAP protein, humanFibroblast Activation Protein AlphaFluorodeoxyglucose F18Gallium-68Gallium RadioisotopesQuinolinesRadiopharmaceuticalsCUPExtra-cervicalFAPIFDGOligometastaticSingle-site

Identifiers

PMID42171731
PMCPMC13421285

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.