Evidence map›Paper›PMID 42171709›Full record

ArticleActa diabetologica2026

Differences in physiological response to an oral glucose tolerance test in adult Maasai men and women.

Dirk Lund Christensen, Cathrine Olesen Emborg, Kaushik Laxmidas Ramaiya, Venance Philip Maro, Ib Christian Bygbjerg, Joseph Sironga, Jens Juul Holst, Kajiru Kilonzo, Bolette Hartmann, Flemming Dela and 2 more

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Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Dirk Lund ChristensenDepartment of Public Health, Section of Global Health, University of Copenhagen, CSS Campus, Building 9, Copenhagen, 1014, Denmark. dirklc@sund.ku.dk.ORCID http://orcid.org/0000-0003-2142-522X
Cathrine Olesen EmborgDepartment of Public Health, Section of Global Health, University of Copenhagen, CSS Campus, Building 9, Copenhagen, 1014, Denmark.
Kaushik Laxmidas RamaiyaShree Hindu Mandal Hospital, Dar es Salaam, Tanzania.
Venance Philip MaroSchool of Medicine, KCMC University, Moshi, Tanzania.
Ib Christian BygbjergDepartment of Public Health, Section of Global Health, University of Copenhagen, CSS Campus, Building 9, Copenhagen, 1014, Denmark.
Joseph SirongaSchool of Medicine, KCMC University, Moshi, Tanzania.
Jens Juul HolstDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kajiru KilonzoSchool of Medicine, KCMC University, Moshi, Tanzania.
Bolette HartmannDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Flemming DelaDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Steen LarsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jørn Wulff HelgeDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsRural, agro-pastoralist Maasai in East Africa exhibit low prevalence of diabetes, yet little is known about their physiological response to glucose loads and whether sex has an impact on glucose metabolism, including incretin hormones.

methodsWe included 58 (29 men, 29 women) adult Maasai without diabetes living in rural Tanzania. Clinical background characteristics were measured, and they were exposed to an oral glucose tolerance test (OGTT) after an overnight fast. Plasma glucose, insulin/C-peptide, glucagon, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) were analysed.

resultsMean age was 34.8 (range 17-65) years, and mean body mass index (BMI) was 20.3 (range 14.0-30.9) kg/m

conclusionsSex differences were found in fasting glucose and OGTT-derived insulin/C-peptide and GLP-1 concentrations. Research using more sophisticated methodology is needed to further explain the glucose metabolism phenotype in Maasai people.

Indexed as

Blood GlucoseAdolescentAdultAgedBody Mass IndexC-PeptideFemaleGastric Inhibitory PolypeptideGlucagonGlucagon-Like Peptide 1Glucose Tolerance TestHumansInsulinMaleMiddle AgedSex FactorsBlood GlucoseC-PeptideGastric Inhibitory PolypeptideGlucagonGlucagon-Like Peptide 1InsulinIncretin hormonesMaasaiOral glucose tolerance testSex differencesSub-Saharan Africa

Identifiers

PMID42171709
PMCPMC13468978

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