Evidence map›Paper›PMID 42171673›Full record

ArticleJournal of endocrinological investigation2026

Thyroid abnormalities in acromegaly in the era of improved disease control: a two-stage study.

Luciana P S Diniz Leite, Beatriz S Soares da Rocha, Gustavo A P Diniz Leite, Gabriel A P Diniz Leite, Juliana Beaudette Drumond, Lucas G de O Freitas, Izabella S Freitas, Ângela C Leal, Nathalie O Santana, Adriana M Lamego Rezende and 6 more

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Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

16 authors.

Luciana P S Diniz LeiteDivision of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Beatriz S Soares da RochaDepartment of Endocrinology of the Federal University of Minas Gerais, Belo Horizonte, 30130-100, MG, Brazil.
Gustavo A P Diniz LeiteFaculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, 30130-100, MG, Brazil.
Gabriel A P Diniz LeiteFaculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, 30130-100, MG, Brazil.
Juliana Beaudette DrumondDepartment of Endocrinology of the Federal University of Minas Gerais, Belo Horizonte, 30130-100, MG, Brazil.
Lucas G de O FreitasFaculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, 30130-100, MG, Brazil.
Izabella S FreitasFaculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, 30130-100, MG, Brazil.
Ângela C LealDivision of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Nathalie O SantanaDivision of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Adriana M Lamego RezendeDepartment of Medical Imaging of the Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Enaldo V MeloStatistics division, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Arthur M Pereira OliveiraDivision of Neurosurgery, Hospital de Cirurgia, Aracaju, Sergipe, 49055-000, Brazil.
Elenilde G SantpsDivision of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Viviane C CamposDivision of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Roberto SalvatoriDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine Baltimore, Baltimore, MD, 21287, USA.
Manuel H Aguiar-OliveiraDivision of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil. herminio.endo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAcromegaly is associated with increased risk of diffuse or nodular goiter and possibly of thyroid cancer. The aim of this study was to verify whether these findings persist in the current scenario of improved disease control.

methodsA two-steps protocol was carried out:. In the first (retrospective), clinical and laboratory data (including 969 IGF-I measurements), and the frequency of thyroid cancer were recorded for 92 acromegaly patients over a 28-year period. The annual control percentage was defined as the average of the ratios between each of the 969 IGF-I measurements over the total follow-up period and the respective upper age limit (IGF-I/ULN) less than 1.Acromegaly activity was determined at the last visit. In the second step (cross-sectional), 74 of the 92 acromegaly patients underwent thyroid ultrasound and were subjected to a two-stage cluster analysis, with the aim of grouping them into homogeneous clusters.

results70% of the 92 patients had inactive disease, with a median control rate of 50%, with four cases of thyroid cancer (4.3%), only one in a patient with active disease. Two-thirds of the 74 patients (evaluated by ultrasound) had nodules, and 27% had diffuse thyroid hyperplasia. Three clusters were segregated with high significant differences in sex and echotextural alterations (p < 0.0001 in both cases). Age, number of nodules, thyroid volume and follow-up time were similar between the clusters.

conclusionNo inherent thyroid changes were apparently identified in a large cohort of acromegaly patients. Better control during follow-up may attenuate thyroid manifestations in acromegaly.

Indexed as

AcromegalyThyroid DiseasesThyroid GlandThyroid NeoplasmsAdultAgedCross-Sectional StudiesFemaleFollow-Up StudiesHumansInsulin-Like Growth Factor IMaleMiddle AgedRetrospective StudiesInsulin-Like Growth Factor IAcromegalyGrowth hormoneInsulin-like growth factorThyroid gland

Identifiers

PMID42171673
PMCPMC13498476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.