ArticleJournal of endocrinological investigation2026
Beyond MRI: Unveiling metabolic signatures of primary hypophysitis with
Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsHypophysitis is a heterogeneous clinical entity originating from different anatomical compartments of the pituitary gland and driven by diverse pathophysiological mechanisms. This study aims to explore the potential diagnostic and clinical value of MATERIALS AND
methodsThis single-center retrospective study was conducted at the pituitary referral unit of a tertiary university hospital. The study population included patients with primary hypophysitis, individuals with nonfunctioning pituitary adenomas, and subjects without intracranial pathology. Demographic features, baseline clinical and biochemical characteristics, as well as initial cranial and sellar magnetic resonance imaging and
resultsA total of 46 participants were enrolled in the study, comprising 16 patients with primary hypophysitis, nine with nonfunctioning pituitary adenoma, and 21 controls without intracranial pathology. Positron emission tomography demonstrated significantly higher maximum and mean standardized uptake values in patients with primary hypophysitis compared with controls, whereas no significant differences were observed between the other groups. Within the primary hypophysitis cohort, mean standardized uptake values were significantly elevated in patients with hypopituitarism and in those with Arginine vasopressin deficiency (central diabetes insipidus) compared to their respective counterparts without these conditions. Furthermore, both maximum and mean standardized uptake values were markedly higher in patients with growth hormone deficiency than in those with preserved growth hormone function.
conclusionThese findings suggest that metabolic activity observed on
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