ArticleJACC. Case reports2026
Acute Aortic Dissection Associated With Cancer Therapy in a Previously Normal Aorta.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Aortic Dissection Without Dilatation: Expanding Risk Paradigms in Cardio-Oncology.JACC. Case reports · 2026Article
- Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProphylactic management for aortic dissection, a life-threatening emergency, is traditionally guided by aortic diameter. CASE SUMMARY: A 60-year-old man, on pembrolizumab and lenvatinib for recurrent clear cell renal cell carcinoma, presented with chest pain, hypotension, and bradycardia during pembrolizumab infusion. Despite previously normal aortic dimensions on sequential imaging, computed tomography aortography revealed Stanford type A dissection requiring urgent surgery. DISCUSSION: This case supports emerging evidence for an association between acute aortic syndromes and modern cancer therapies, even in patients without structural warning signs. The potential for acquired aortic wall disease without associated dilatation cautions against risk stratification based only on aortic dimensions. TAKE-HOME MESSAGES: Cancer therapy-related vascular toxicity may predispose to acute aortic syndromes through acquired aortic wall vulnerability, even in the absence of prior aortic dilatation. This highlights the limitations of diameter-based risk stratification and the need for vigilant clinical assessment and strict blood pressure control.
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