Ultrasound-Guided Extraluminal Venous Valve Functional Remodeling.

Weipu Zou, Meijia Xu, Qianqian Jia, Yuefeng Zhu

Registry-linked trialAbstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05914740 (Feasibility Study of Ultrasound-guided Functional Remodeling of Lower Extremity Superficial Venous Valve), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05914740 naunknown statusnot on this map

Feasibility Study of Ultrasound-guided Functional Remodeling of Lower Extremity Superficial Venous Valve

TypeinterventionalSponsorThe Fourth Affiliated Hospital of Zhejiang University School of MedicineRan2023 to 2024Enrolled10ConditionsVaricose Veins of Lower LimbArmsUltrasound guided functional remodeling of lower extremity superficial vein valve

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weipu ZouDepartment of Ultrasound in Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Meijia XuDepartment of Vascular Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Qianqian JiaPostdoctoral Research Station, Hangzhou Singclean Medical Products Co, Ltd, Hangzhou, China.

Yuefeng ZhuDepartment of Vascular Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address: srrshzyf@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndovenous treatment for varicose veins is predominantly ablative, whereas vein-preserving approaches remain limited. CASE SUMMARY: A 60-year-old man with left lower extremity varicose veins and pruritus underwent ultrasound-guided extraluminal circumferential hyaluronic acid injection around the incompetent terminal valve at the left saphenofemoral junction after duplex ultrasound confirmed primary superficial venous valve incompetence. Immediate and early follow-up duplex ultrasound showed abolition of reflux, with brief reflux <0.5 seconds at 3 months and recurrent reflux >0.5 seconds at 12 months. No procedure-related complications occurred. DISCUSSION: This case documents immediate and stage-dependent changes in venous valve behavior after a vein-preserving extraluminal intervention and highlights the role of duplex ultrasound in guidance and serial assessment. TAKE-HOME MESSAGES: Extraluminal intervention may induce short-term changes in reflux without vein ablation. Durability and clinical significance require further study. (Feasibility Study of Ultrasound-guided Functional Remodeling of Lower Extremity Superficial Venous Valve; NCT05914740).

Indexed as

extraluminal venous valve functional remodelinghyaluronic acidlower extremity varicose veinsultrasound guidance

Identifiers

PMID42171574

DOI10.1016/j.jaccas.2026.108393

PMCPMC13326202

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LicenceCC BY-NC-ND

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Registered trials

NCT05914740ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.