ArticleACS chemical neuroscience2026
Lactational Serotonergic Perturbation Imprints Stress-Related Transcriptional Profiles in the Adolescent Female Rat Prefrontal Cortex.
Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life perturbations of serotonin (5-hydroxytryptamine, 5-HT) signaling induce long-term neurobehavioral consequences. We previously demonstrated that perinatal manipulation of the 5-HTergic system in rats leads to distinct adult biobehavioral outcomes depending on sex and time of intervention, with postnatal manipulations leading to cognitive deficits in females. Moreover, we showed that prenatal disruption of 5-HT signaling alters the response to acute stress in male adolescents. Here, we investigated whether postnatal exposure to the selective serotonin reuptake inhibitor fluoxetine (FLX) affects adolescent behavior and molecular stress responsivity. Rats were exposed to FLX during the lactation period and behaviorally characterized during adolescence to assess distinct psychiatric-like phenotypes. Transcriptional responses to acute restraint stress (ARS) were evaluated in the prefrontal cortex (PFC) and the dorsal and ventral hippocampus. Although no behavioral alterations were detected, postnatal FLX exposure modified the ARS-induced molecular response. In particular, females exposed to FLX during lactation showed a blunted induction of immediate early genes, early response genes, and brain-derived neurotrophic factor isoforms in the PFC. These findings indicate an altered stress-responsive transcriptional profile that may represent an early molecular alteration preceding the cognitive deficits previously observed selectively in adult females.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.