Evidence map›Paper›PMID 42170637›Full record

ArticleIranian journal of pharmaceutical research : IJPR

Four Steroidal Saponins Isolated from the Aerial Parts of

Saeid Eslami, Behzad Zolfaghari, Masoud Sadeghi Dinani, Arezoo Mirzaee, Hajar Sirous, Mustafa Ghanadian

Abstract read
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In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saeid EslamiDepartment of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0009-0004-6538-2609
Behzad ZolfaghariDepartment of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0001-7087-2590
Masoud Sadeghi DinaniDepartment of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Arezoo MirzaeeDepartment of Bacteriology and Virology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
Hajar SirousDepartment of Bioinformatics, Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Mustafa GhanadianDepartment of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID https://orcid.org/0000-0001-6446-4734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Global health security is critically threatened by multidrug-resistant Gram-negative bacteria, which frequently overexpress efflux pumps to expel antibiotics, rendering last-resort drugs like colistin ineffective and diminishing treatment options. Methods: This study investigated the antibacterial and antibiofilm potential of four steroidal saponins isolated from the aerial parts of Results: Four steroidal-type saponins were isolated. Bioactivity assays revealed that compounds 1 - 3 exhibited minimum inhibitory concentrations (MICs) of 4 mg/mL against colistin-resistant pathogens: Conclusions: These findings highlight the saponin profile in aerial parts of edible plant

Indexed as

Allium jesdianumAnti-biofilmColistin-resistantEfflux PumpsMolecular dockingMultidrug resistanceSteroidal Saponins

Identifiers

PMID42170637
PMCPMC13187685

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.