ArticleJournal of human immunity2025
Clinical features, genotypes, and geographic distribution of 238 Latin American CGD patients.
Abstract read
In one paragraph
Article in Journal of human immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond.Journal of human immunity · 2026Article
- Chronic granulomatous disease: Clinical, microbial, and genetic findings in 39 Colombian patients.Journal of human immunity · 2026Article
- Perspectives on chronic granulomatous disease: results of a clinician survey.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
70 authors.
Tiago Santos de OliveiraDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1348-8661
Ranieri Coelho SalgadoDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9660-9747
Lillian Nunes GomesDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0429-2074
Carolina Sanchez ArandaDepartment of Pediatrics, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2187-8192
Janáira Fernandes Severo FerreiraAlbert Sabin Children's Hospital, Fortaleza, Brazil.ORCID https://orcid.org/0000-0002-3999-6939
Ekaterini Simões GoudourisFederal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-1937-9124
Fernanda Pinto MarizFederal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-6981-2352
Maria Luiza Oliva AlonsoFederal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-7879-7134
Solange Oliveira Rodrigues ValleFederal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-5512-7349
Luiz Fernando Bacarini LeiteSanta Casa de Misericórdia de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5581-0444
Ana Carolina da Matta AinTaubaté University - Municipal University Hospital of Taubaté, Taubaté, Brazil.ORCID https://orcid.org/0000-0001-6188-6317
Pérsio Roxo-JuniorFaculty of Medicine of the University of São Paul, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0001-6318-4132
Marília MontanaroFaculty of Medicine of the University of São Paul, Ribeirão Preto, Brazil.ORCID https://orcid.org/0009-0005-1469-7894
Flávia Alice Timburibá de Medeiros GuimarãesBrasilia Mother and Child Hospital, Brasília, Brazil.ORCID https://orcid.org/0009-0005-0796-4691
Simone de Castro Resende FrancoBrasilia Mother and Child Hospital, Brasília, Brazil.ORCID https://orcid.org/0009-0001-3444-2945
Herberto José Chong-NetoDivision of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.ORCID https://orcid.org/0000-0002-7960-3925
Nelson Augusto Rosario FilhoDivision of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.ORCID https://orcid.org/0000-0002-8550-8051
Daniélli Christinni Bichuetti-SilvaFederal University of Goias, Goiania, Brazil.ORCID https://orcid.org/0000-0003-4861-1401
Vera Maria DantasFederal University of Rio Grande do Norte, Natal, Brazil.ORCID https://orcid.org/0000-0001-6687-3304
Jackeline Motta FrancoFederal University of Sergipe, Aracajú, Brazil.ORCID https://orcid.org/0000-0003-3088-492X
Viviane Guimaro Mendes Barreto ResendeRegional Hospital of Mato Grosso do Sul, Campo Grande, Brazil.ORCID https://orcid.org/0009-0004-5384-5864
Simone Soares LimaLucidio Portela Children's Hospital, Teresina, Brazil.ORCID https://orcid.org/0000-0002-3013-8778
Dorcas Lamounier CostaLucidio Portela Children's Hospital, Teresina, Brazil.ORCID https://orcid.org/0000-0001-7115-7978
Mayra De Barros DornaChildren's Institute, Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0168-7807
Antônio Carlos PastorinoChildren's Institute, Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2756-627X
Beni MorgensternChildren's Institute, Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2607-3972
Vera Esteves Vagnozzi RulloSantos Faculty of Medical Sciences, Lusíada University Center, Santos, Brazil.ORCID https://orcid.org/0000-0002-4754-6612
Constantino Giovanni Braga CartaxoDepartment of Pediatrics and Genetics, Federal University of Paraíba, João Pessoa, Brazil.ORCID https://orcid.org/0000-0002-6763-6594
Naiade R de SáDepartment of Pediatrics and Genetics, Federal University of Paraíba, João Pessoa, Brazil.ORCID https://orcid.org/0000-0003-1114-028X
Irma Cecília Douglas Paes BarretoUniversity Center of the State of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0001-6847-9546
Nancy Viegas Chen LoboPrivate Office, Maceió, Brazil.ORCID https://orcid.org/0009-0007-8262-7147
Flavia Amendola Anisio de CarvalhoFernandes Figueira Institute, Fiocruz, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-6135-4927
Monica Soares de SouzaHead of Pediatric Immunoallergy at the Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0003-6841-3792
Gesmar Rodrigues Silva SegundoFederal University of Uberlandia, Uberlândia, Brazil.ORCID https://orcid.org/0000-0001-6310-1739
Dewton de Moraes VasconcelosChildren's Cancer Treatment Institute, Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3930-3354
Juliana Folloni FernandesChildren's Cancer Treatment Institute, Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5764-1621
Gislene Santana TusaniChildren's Cancer Treatment Institute, Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0009-0008-9479-0926
Carolina Cardoso de Mello PrandoInsituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Hospital Pequeno Príncipe, Curitiba, Brazil.ORCID https://orcid.org/0000-0002-9570-9770
Ana Paula Zaninelli Diniz IwamuraInsituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Hospital Pequeno Príncipe, Curitiba, Brazil.ORCID https://orcid.org/0000-0003-0645-2975
Arturo López-LariosUnidad de Inmunología Clínica, Hospital CIMA, Hermosillo, Mexico.ORCID https://orcid.org/0009-0005-3119-4789
Ana Jocelyn Carmona VargasDepartamento de Enfermedades Infecciosas, Instituto Nacional de Pediatria, Mexico city, Mexico.ORCID https://orcid.org/0009-0003-8173-6596
Ana Paola Macías-RoblesDepartamento de Alergia e Inmunología Clínica Pediátrica, UMAE, CMNO, Guadalajara, Mexico.ORCID https://orcid.org/0000-0003-1413-6526
Maria Edith Gonzalez SerranoImmunodeficiencies Laboratory, Instituto Nacional de Pediatria, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-2779-0466
Sara Elva Espinosa-PadillaImmunodeficiencies Laboratory, Instituto Nacional de Pediatria, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-4859-3151
Ana Karen Peñafiel VicuñaImmunodeficiencies Laboratory, Instituto Nacional de Pediatria, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-3496-2633
Aidé Tamara Staines-BooneDepartamento de Inmunología, UMAE, Monterrey, Mexico.ORCID https://orcid.org/0000-0003-0776-8162
Omar J Saucedo-RamírezDepartamento de Alergia, Hospital infantil de México Federico Gómez, Mexico City, Mexico.ORCID https://orcid.org/0000-0001-9193-0091
Miguel García DomínguezHospital Pediátrico de Sinaloa "Dr. Rigoberto Aguilar Pico," Culiacan, México.ORCID https://orcid.org/0000-0002-2915-0489
Maria R Canseco-RaymundoDepartamento de Alergia e Inmunología Clínica, UMAE, "LA RAZA," Mexico City, México.ORCID https://orcid.org/0000-0002-1567-7941
Federico Saracho-WeberDepartamento de Enseñanza, Hospital Infantil de Especialidades, Mexico City, México.ORCID https://orcid.org/0000-0003-1174-936X
Oscar Zavaleta MartínezAllergy and Immunology Department, Hospital Materno Infantil, Instituto de Seguridad Social del Estado de México y Municipios, Toluca, Mexico.ORCID https://orcid.org/0000-0003-0643-0936
Susana García-Pavón-OsorioHigh Specialty Naval Hospital, Mexico City, Mexico.ORCID https://orcid.org/0000-0001-8307-7772
Rogelio Guzmán CotayaChavitos Clinic, Merida, Mexico.ORCID https://orcid.org/0009-0002-8519-7473
Francisco J Espinosa-RosalesFundación Mexicana para Niños y Niñas con Inmunodeficiencias, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-7629-1647
Roselia Ramírez-RiveraDepartamento de Pediatría, Hospital de Especialidades del Niño y la Mujer, "Dr Felipe Nuñez Lara," Querétaro, Mexico.ORCID https://orcid.org/0009-0007-3827-7303
María de la Luz H García-CruzDepartamento de Otorrinolaringologia y Cirugía de Cabeza y Cuello, Instituto Nacional de Enfermedades Respiratorias, Mexico city, México.ORCID https://orcid.org/0000-0002-5656-5196
Carmen Zarate-HernándezCentro Regional de Alergia e Inmunología Clínica, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.ORCID https://orcid.org/0000-0002-0105-2756
Lizbeth Blancas-GaliciaImmunodeficiencies Laboratory, Instituto Nacional de Pediatria, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-3861-8864
Alejandra KingFacultad de Medicina, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-0396-9872
Oscar PorrasHospital Nacional de Ninos "Dr Carlos Saenz Herrera," San Jose, Costa Rica.ORCID https://orcid.org/0000-0002-0892-6225
Lorena RegairazUnidad de Inmunología, Hospital de Niños Sor María Ludovica, Buenos Aires, Argentina.ORCID https://orcid.org/0009-0002-7290-4079
Alejandra LampugnaniHospital Rawson, San Juan, Argentina.ORCID https://orcid.org/0009-0006-7147-0132
Celia Martínez de CuellarUniversidad Nacional de Asunción, San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0003-3683-590X
Juan Carlos Aldave BecerraDivision of Allergy and Immunology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.ORCID https://orcid.org/0000-0003-3548-0385
Liz Eliana Veramendi EspinozaOficina General de Investigación y Transferencia Tecnológica, Instituto Nacional de Salud, Lima, Peru.ORCID https://orcid.org/0000-0002-6998-9529
Cecilia MontenegroCentro Hospitalario Pereira Rossell, Montevideo, Uruguay.ORCID https://orcid.org/0000-0003-0263-7868
Magdalena SchelottoCentro Hospitalario Pereira Rossell, Montevideo, Uruguay.ORCID https://orcid.org/0000-0001-8723-1239
Virginia PatiñoCentro Hospitalario Pereira Rossell, Montevideo, Uruguay.ORCID https://orcid.org/0000-0002-9467-4270
Mariane Cunha de OliveiraCentro Universitário das Faculdades Metropolitanas Unidas, São Paulo, Brazil.ORCID https://orcid.org/0009-0007-5998-7398
Antonio Condino-NetoDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1069-3117
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI) caused by mutations in genes encoding components of the NADPH oxidase complex, leading to defective microbial killing and increased susceptibility to infections. This study analyzed clinical, genetic, and geospatial data from 238 CGD patients across eight Latin American countries. Genetic variants were identified in 141 patients (59%), with XL-CGD being the most common form (77%). Pneumonia (80%), lymphadenopathy (63%), and skin infections (55.5%) were frequent, with bacteria and fungi, such as
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