ArticleComprehensive psychoneuroendocrinology2026
Metabolic syndrome severity is related to perceived discrimination and stress in the all of us cohort.
Article in Comprehensive psychoneuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Metabolic-syndrome (MetS) is influenced by underlying physiologic processes potentially worsened by social determinants of health. Our goal was to assess whether MetS severity was associated with scores on scales assessing perceived discrimination and stress. Methods: We assessed data from 25,969 participants without diabetes in the All-of-Us cohort for how a MetS-severity-z-score (MetS-Z) was related to SDoH scales for Everyday Discrimination (EDS), Discrimination in Medical Settings (DMS), and Perceived Stress (PSS). Regression models adjusted for sex, self-reported race and ethnicity, income, education and age-group, and evaluated for potential interactions between score, sex, race and ethnicity and age. Results: All three discrimination and stress scores were positively associated with MetS-severity (slopes: EDS 0.071 ± 0.007, DMS 0.085 ± 0.009, PSS 0.006 ± 0.001, all p < 0.001). Regarding racial differences, there was a greater slope in the association between EDS and MetS-Z among White and Other individuals compared to Black individuals. Regarding interactions between sex and race and ethnicity, associations between DMS and MetS-Z were greater among White and Other females compared to White and Other males. There was no difference in the relationship between PSS score and MetS-Z between racial/ethnic group or sex. For each scale, relationships were stronger among younger (age 18-39 and 40-59-years) compared to older (age ≥60 years) individuals, with the strongest relationships among the 40-59-year group. Conclusions: Perceived discrimination and stress were consistently-albeit weakly-associated with MetS-severity, supporting potential connections with physiologic processes increasing cardiometabolic disarray. Unexpectedly, in this analytic cohort the relationship between everyday discrimination and MetS-severity by race and ethnicity was strongest among White and Other individuals.
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