Evidence map›Paper›PMID 42170521›Full record

ArticleRSC chemical biology2026

Bronwyn E Rowland, Kelsey D Roy, Adil Alkaş, Mirele Barsoum, Tangweth Kuot, Jesse C Fuller, Adrien J Naudet, Elisa Ospanow, David L Jakeman

Abstract read
In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bronwyn E RowlandDepartment of Chemistry, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada david.jakeman@dal.ca.ORCID https://orcid.org/0009-0009-2022-6609
Kelsey D RoyCollege of Pharmacy, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada.
Adil AlkaşDepartment of Chemistry, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada david.jakeman@dal.ca.ORCID https://orcid.org/0000-0002-9375-7963
Mirele BarsoumDepartment of Chemistry, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada david.jakeman@dal.ca.
Tangweth KuotCollege of Pharmacy, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada.
Jesse C FullerDepartment of Chemistry, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada david.jakeman@dal.ca.
Adrien J NaudetFaculté de Pharmacie, Université Grenoble Alpes Grenoble 38400 France.
Elisa OspanowDepartment of Chemistry, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada david.jakeman@dal.ca.
David L JakemanDepartment of Chemistry, Dalhousie University Halifax Nova Scotia B3H 4R2 Canada david.jakeman@dal.ca.ORCID https://orcid.org/0000-0003-3002-3388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Certain drugs achieve highly potent and long-lasting enzyme inhibition by forming covalent bonds with nucleophilic amino acid functionalities. Aldehyde-containing inhibitors are able to react with lysine ε-amino functionalities to form reversible-covalent imine (Schiff base) adducts.

Identifiers

PMID42170521
PMCPMC13189197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.