ArticleBiological psychiatry global open science2026
Insular Somatostatin Interneurons Are Targeted by Motor Cortex Efferents and Modulate Affective States.
Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- From Efference Copy to Emotional State: Insular Cortex Somatostatin Neurons Buffer Adaptive Responses to Physical Stress.Biological psychiatry global open science · 2026Article
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7 authors.
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Abstract
Background: Stress-related psychiatric disorders often involve disrupted corticolimbic communication. The mid-insular cortex (mIC) negatively regulates affective behavior through projections to the bed nucleus of the stria terminalis (BNST); however, the architecture of synaptic governance of this path is not clear. The primary motor cortex (MOp) provides substantial input to the mIC; however, the extent of the input remains unknown. Methods: We used anterograde and retrograde tracing, whole-cell patch-clamp electrophysiology, fiber photometry, and chemogenetics to investigate MOp innervation of the mIC (MOp Results: MOp afferents form excitatory synapses onto mIC SST-INs, which in turn inhibit mIC Conclusions: Our findings uncover a novel motor afferent-driven inhibitory circuit within the mIC that preferentially targets SST-INs that regulate affective behavior, providing insight into potential targets for therapeutic intervention in stress-related affective disorders.
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