ArticleCureus2026
Dowling-Degos-Like Flexural Hyperpigmentation in a Two-Year-Old Saudi Girl.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Dowling-Degos disease (DDD) is a rare, autosomal dominant pigmentary disorder typically characterized by adult-onset reticulate hyperpigmentation in flexural areas. Early-onset cases are exceptionally rare. A two-year-old Saudi girl presented with a one-year history of progressive, asymptomatic, velvety hyperpigmented plaques involving the axillae, anogenital region, and face. Histopathological analysis showed epidermal acanthosis with elongated rete ridges and prominent basal hyperpigmentation, consistent with DDD. Immunohistochemistry (SOX10) confirmed increased melanocytes at the rete ridge tips. This report describes what is, to our knowledge, the earliest documented case of DDD-like pigmentation in a patient under three years of age. It underscores the vital role of histopathological correlation in diagnosing pediatric pigmentary disorders, especially when genetic evaluations are inconclusive, and highlights the need for further research into the genotype-phenotype variations of early-onset disease.
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