ArticleThe Lancet regional health. Southeast Asia2026
Intrinsic capacity and survival among older adults in India: LASI-DAD study (wave 1 and wave 2).
Article in The Lancet regional health. Southeast Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Intrinsic capacity and the physical frailty phenotype as complementary predictors of mortality in older Indian adults.Research square · 2026Article
- Seven routine blood markers predict five-year mortality in older Indians: a risk score from the LASI-DAD cohort.Research square · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
Background: With increasing longevity, the focus of healthcare for older adults is shifting from a disease-centric model to a more holistic view of functional capacity. This study investigates the relationship between intrinsic capacity (IC)-a measure of combined physical and mental abilities-and survival among older adults in India. Methods: We analysed data from 4096 community-dwelling individuals aged 60 and older who participated in the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD). IC was evaluated across six domains: cognition, mood, nutrition, locomotion, vision, and hearing. An overall IC score was created by aggregating the z-scores from these domains. Cox Model was used to determine if IC was a predictor of mortality, adjusting for confounding factors. Findings: During the follow-up period, 951 participants (23.2%) died. A higher IC score was associated with a lower risk of death (Hazard Ratio (HR): 0.89; 95% CI: 0.86-0.91). The risk of mortality increased progressively with the number of impaired intrinsic capacity domains: participants with one impaired domain had a HR of 1.48 (95%CI 1.26-1.75); two impaired domains, HR: 2.10 (95%CI 1.67-2.65); three impaired domains, HR: 1.71 (95%CI 1.14-2.57); and four impaired domains, HR: 3.15 (95%CI 1.53-6.46). Of the six domains, cognition, nutrition, and locomotion were identified as the strongest predictors of survival. Vision impairment did not show a independent association with mortality. Interpretation: Older adults in India with higher overall intrinsic capacity-particularly better cognition, good nutrition, and better locomotor capacity-had a lower risk of death. These findings highlight the importance of looking at functional abilities, not just diseases, when planning health care and interventions for ageing populations. Funding: LASI-DAD is funded by the National Institute on Aging, the National Institutes of Health (R01 AG051125, U01AG064948).
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