Evidence map›Paper›PMID 42170343›Full record

ArticleChemical science2026

pH-activatable brominated pentamethine cyanine dyes for imaging-guided photodynamic immunotherapy of tumors.

Wangna Tang, Yanbing Cao, Ran Wang, Tian Qiu, Yingqi Hu, Shaoyang Shi, Xiaolong Zeng, Jiangli Fan, Wen Sun, Xiaojun Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wangna TangState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Yanbing CaoState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Ran WangState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Tian QiuState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Yingqi HuState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Shaoyang ShiState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Xiaolong ZengState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.
Jiangli FanState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.ORCID https://orcid.org/0000-0003-4962-5186
Wen SunState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.ORCID https://orcid.org/0000-0003-4316-5350
Xiaojun PengState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology Dalian 116024 China sunwen@dlut.edu.cn yanbingcao@dlut.edu.cn.ORCID https://orcid.org/0000-0002-8806-322X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) has emerged as a minimally invasive antitumor strategy, yet conventional photosensitizers often suffer from off-target phototoxicity under physiological conditions. This study presents a novel pH-activatable brominated pentamethine cyanine dye (C-CyBr) as a smart photosensitizer for imaging-guided photodynamic therapy (PDT). A hydroxylated indole moiety was rationally introduced as the pH-sensitive switch. Under neutral physiological pH (7.4), the dye exists in a closed-ring non-fluorescent and photoinert state with negligible reactive oxygen species (ROS) generation and fluorescence emission. In contrast, once exposed to the acidic tumor microenvironment (pH ≤ 6.5, the critical activation threshold), the hydroxyl group undergoes rapid protonation, which restores the conjugated π-electron system, activates fluorescence imaging signals and simultaneously unlocks the photosensitizing activity. C-CyBr was further used to prepar nanoparticles (OCBr), which exhibit excellent tumor accumulation

Identifiers

PMID42170343
PMCPMC13187947

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.