Evidence map›Paper›PMID 42170315›Full record

ArticleEuropean heart journal. Imaging methods and practice2025

Reduced myocardial work in Fontan circulation: feasibility, reproducibility, and diagnostic performance.

Jolanda Sabatino, Roberta Biffanti, Martina Avesani, Elena Reffo, Alessia Cerutti, Biagio Castaldi, Alice Pozza, Irene Cattapan, Elena Gribaudo, Valeria Pergola and 3 more

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Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Jolanda SabatinoDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 1,Catanzaro 88100, Italy.ORCID https://orcid.org/0000-0002-1661-5419
Roberta BiffantiPediatric and Congenital Cardiology Unit, University Hospital of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Martina AvesaniDepartment for Women's and Children's Health, University of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Elena ReffoPediatric and Congenital Cardiology Unit, University Hospital of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Alessia CeruttiPediatric and Congenital Cardiology Unit, University Hospital of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Biagio CastaldiDepartment for Women's and Children's Health, University of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Alice PozzaDepartment for Women's and Children's Health, University of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Irene CattapanDepartment for Women's and Children's Health, University of Padua, Via Giustiniani, 2, Padua 35128, Italy.
Elena GribaudoPediatric Cardiology and Congenital Heart Disease Unit, Regina Margherita Children's Hospital, Piazza Polonia, 94, Turin 10126, Italy.
Valeria PergolaDepartment of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Via Giustiniani, 2, Padua 35128, Italy.ORCID https://orcid.org/0000-0002-3317-7342
Salvatore De RosaDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 1,Catanzaro 88100, Italy.ORCID https://orcid.org/0000-0001-5388-942X
Daniele TorellaDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 1,Catanzaro 88100, Italy.ORCID https://orcid.org/0000-0002-4915-5084
Giovanni Di SalvoDepartment for Women's and Children's Health, University of Padua, Via Giustiniani, 2, Padua 35128, Italy.ORCID https://orcid.org/0000-0002-0305-0113

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To evaluate the feasibility, reproducibility, and diagnostic performance of non-invasive myocardial work (MW) indices in patients with Fontan circulation compared with matched healthy controls. Methods and results: In this single-centre observational study, echocardiography and speckle-tracking analysis were performed in 70 Fontan patients (mean age 21 ± 9 years; 53% male) and age/sex/body size/blood pressure-matched controls. Global longitudinal strain (GLS) and MW indices-myocardial work index (MWI), constructive work (MCW), wasted work (MWW), and work efficiency (MWE)-were derived using vendor software and brachial cuff blood pressure. MW analysis was feasible in 86% of Fontan examinations. Compared with controls, Fontan patients had significantly lower MWI (1162 ± 364 vs. 1777 ± 240 mmHg%, Conclusion: Non-invasive MW indices are feasible and highly reproducible in Fontan circulation and identify reduced ventricular work and efficiency, including in patients with preserved conventional systolic measures. MW may provide a sensitive marker of subclinical myocardial dysfunction and support longitudinal follow-up in this population.

Indexed as

Fontanglobal longitudinal strainmyocardial worksingle ventriclespeckle tracking echocardiographyventricular function

Identifiers

PMID42170315
PMCPMC13188148

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