Evidence map›Paper›PMID 42170304›Full record

ArticleHuman mutation2026

Bioinformatics Combined With Biological Experiments to Explore the Promotion of Lung Metastasis by CCL18 in the Immune Microenvironment of Colorectal Cancer.

Qingcheng Xia, Shuting Yin, Jiping Chen, Haonan Wang, Yexin Shi, Jie Li, Zidong Yuan, Zijun Wang, Ming Lu, Qinghong Zhao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qingcheng XiaDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.ORCID https://orcid.org/0009-0007-4238-2915
Shuting YinDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, China, ahnmc.com.
Jiping ChenDepartment of General Surgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Haonan WangDepartment of Emergency and Pediatric Intensive Care Unit (PICU), Children's Hospital of Nanjing Medical University, Nanjing, China.
Yexin ShiDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Jie LiDepartment of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Zidong YuanDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Zijun WangDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Ming LuDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.
Qinghong ZhaoDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.ORCID https://orcid.org/0000-0003-0326-1436
Wei WeiDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.ORCID https://orcid.org/0000-0002-7772-1135
Xiang MaDepartment of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, njmu.edu.cn.ORCID https://orcid.org/0000-0001-7246-3360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) is one of the most prevalent malignant neoplasms. Tumor metastasis represents a significant contributor to unfavorable prognosis, and lung metastasis is the most common extra-abdominal metastasis of CRC. However, pulmonary metastatic CRC has not received significant attention. Therefore, in this study, our main aim was to discover the key genes for lung metastasis and improve the prognosis of CRC. Methods: Differentially expressed genes (DEGs) between primary tumors and patients with pulmonary metastatic CRC were obtained by analysis of a comprehensive database of gene expression (GEO). DEGs were screened by prognostic survival analysis, TCGA differential expression analysis, and single gene GSEA. Results: Combining the differences in patient prognosis and expression, we found that CCL18 is a key gene in CRC lung metastasis. Macrophage coculture and transwell assay verified the potential of CCL18 in promoting the invasive metastatic ability of CRC cells, as well as the proliferation of CRC cells.

Indexed as

Chemokines, CCColorectal NeoplasmsComputational BiologyLung NeoplasmsTumor MicroenvironmentCell Line, TumorCell MovementCell ProliferationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisPrognosisCCL18 protein, humanChemokines, CC

Identifiers

PMID42170304
PMCPMC13189452

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.