Evidence map›Paper›PMID 42170302›Full record

ArticleHuman mutation2026

Lian Mo, Yue Wu, Yan Zhou, Youcheng He, Lifeng Wei, Chunyu Zhou, Shuyu Cai, Jianye Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Human mutation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lian MoClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0001-1484-9983
Yue WuClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0001-8325-9346
Yan ZhouClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-0352-6951
Youcheng HeClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0007-8079-5569
Lifeng WeiClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-1437-9969
Chunyu ZhouClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0007-4032-6039
Shuyu CaiClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0003-6454-6053
Jianye YuanClinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0003-3728-2083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Although gut microbiota dysbiosis has been associated with irritable bowel syndrome (IBS), the specific roles of individual bacterial strains in the pathogenesis of IBS remain incompletely elucidated. Additionally, whether these bacterial strains exert their effects through the ferroptosis pathway remains unclear. Therefore, this study is aimed at investigating the impact of ferroptosis-related molecules regulated by gut microbiota on IBS development using Mendelian randomization (MR) mediation analysis. Methods: Genome-wide association study (GWAS) data for gut microbiota were acquired from the FINRISK study, and protein quantitative trait loci (pQTL) data were retrieved from the deCODE database. Ferroptosis-related genes and their downstream molecules were identified using the FerrDb V2 database; these molecules were then intersected with pQTL data to obtain ferroptosis-related pQTLs. IBS datasets were derived from the FinnGen R12 database. A two-step MR mediation analysis was performed, with the inverse-variance weighted (IVW) method designated as the primary analytical approach. Eligible results were defined by three criteria: Results: Conclusion:

Indexed as

Bifidobacterium breveFerroptosisIrritable Bowel SyndromeDown-RegulationGastrointestinal MicrobiomeGene Expression RegulationGenome-Wide Association StudyHumansMediation AnalysisMendelian Randomization AnalysisPolymorphism, Single NucleotideQuantitative Trait Lociferroptosisgut microbiotairritable bowel syndromeMendelian randomization

Identifiers

PMID42170302
PMCPMC13189460

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.