ArticleTranslational lung cancer research2026
Timing of definitive pleural intervention within systemic anticancer therapy in malignant pleural effusion from high-response lung cancers: a retrospective single-center cohort study.
Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Malignant pleural effusion (MPE) is a common and serious complication of advanced lung cancer. Although guidelines recommend early definitive intervention, the optimal timing of talc pleurodesis-based definitive intervention in pharmacologically sensitive tumors remains undefined. This study aimed to evaluate whether early pleural intervention (EPI) is associated with MPE control and clinical outcomes in lung cancers with high-response systemic therapies, and to define a clinically meaningful time threshold for EPI. Methods: We conducted a retrospective, single-center, cohort study using the pharmacy database of a tertiary hospital between 2012 and 2024. We screened consecutive patients with Results: A total of 392 patients were screened, 83 patients met eligibility criteria (19 underwent EPI and 64 non-EPI). PE control was significantly achieved in the EPI group (94.7% Conclusions: In this retrospective, single-center cohort study, EPI integrated within a multidisciplinary care was associated with higher rate of short-term MPE control and longer survival in MPE from high-response lung cancers. However, given the retrospective design and the limited cohort size, definitive conclusions cannot be drawn from these findings. Nevertheless, the results suggest that the timing of definitive pleural intervention may play an important role in prognostic outcomes. Prospective studies are warranted to provide more conclusive answers to this important question.
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