ArticleTranslational lung cancer research2026
Accelerating tumor evolution and enhancing immunotherapy efficacy in lung adenocarcinoma based on EXO1 inhibition.
Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Emerging evidence highlights defects in DNA damage repair as critical modulators of tumor immunogenicity, yet the mechanistic interplay between repair pathway dynamics and immune checkpoint inhibitor efficacy remains elusive. This study aims to investigate the role of exonuclease 1 (EXO1), a dual-function nuclease involved in homologous recombination (HR) and mismatch repair (MMR), in immunogenomic regulation and immunotherapy response in lung adenocarcinoma (LUAD). Methods: An integrated multi-omics analysis was performed using LUAD cohorts from The Cancer Genome Atlas (TCGA) to assess EXO1 expression, genomic instability, and prognosis. Functional studies were conducted in syngeneic murine models to evaluate the effects of Exo1 ablation on DNA repair pathway kinetics, mutation burden, tumor evolution, and immune cell infiltration. The response to anti-programmed death receptor-1 (PD-1) therapy was assessed in Exo1-deficient versus control tumors. Results: EXO1 overexpression was strongly associated with genomic instability and poor prognosis in LUAD (hazard ratio =1.047, P =3.72×10 Conclusions: This work deciphers DNA damage repair‑immune crosstalk governed by biased repair kinetics, and nominates
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