Evidence map›Paper›PMID 42170220›Full record

ArticleTherapeutics and clinical risk management2026

Effects of TUS-NMES Combined with Glucocorticoid on Clinical Outcomes and Rehabilitation Efficacy of Neurosyphilis Patients with Cerebral Infarction.

Jun Dai, Fanghua He, Yating Xu, Na Lei, Dan Zhang, Wenchao He, Fengfeng Zhu, Shuangshuang Chen, Xinyi Shan, Minzhi Wu and 1 more

Abstract read
In one paragraph

Article in Therapeutics and clinical risk management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun DaiDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Fanghua HeDepartment of Dermatology, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Yating XuDepartment of Dermatology, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Na LeiDepartment of Dermatology, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Dan ZhangDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Wenchao HeDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Fengfeng ZhuDepartment of Intensive Care Unit, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Shuangshuang ChenDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Xinyi ShanDepartment of Rehabilitation, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Minzhi WuDepartment of Dermatology, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Xuehua ZhangDepartment of Inpatient, The Fifth People's Hospital of Suzhou/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.ORCID 0009-0009-1023-8577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effects of transcranial ultrasound-neuromuscular electrical stimulation (TUS-NMES) combined with glucocorticoid (GC) as adjunctive intervention to standard penicillin therapy on clinical outcomes and rehabilitation efficacy in neurosyphilis (NS) patients with cerebral infarction. Methods: A total of 309 NS patients with cerebral infarction were randomly divided into general group (N = 79, penicillin), GC group (N = 77, penicillin and GC), TUS-NMES group (N = 75, penicillin and TUS-NMES), and combination group (N = 78, penicillin and GC & TUS-NMES). Baseline data, clinical symptoms, laboratory indicators, Fugl-Meyer assessment scale (FMA), and National Institute of Health stroke scale (NIHSS) scores before and after treatment were compared. Twelve-month rehabilitation outcomes were analyzed using Kaplan-Meier curves. Results: No serious adverse events occurred during treatment; only mild, transient discomforts, including slight scalp tingling, local muscle tremor, headache, and insomnia, were reported, all of which were alleviated after timely management and did not significantly affect the treatment process or patient recovery. After treatment, all groups showed significant improvement ( Conclusion: TUS-NMES combined with GC, as an adjunct to standard penicillin therapy, improves clinical symptoms, coagulation, and neurological function, and enhances rehabilitation outcomes in NS patients with cerebral infarction.

Indexed as

glucocorticoidnational institute of health stroke scaleneurosyphilis & cerebral infarctiontranscranial ultrasound-neuromuscular electrical stimulation

Identifiers

PMID42170220
PMCPMC13189074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.