Evidence map›Paper›PMID 42170170›Full record

ArticleACG case reports journal2026

The Worst of Both Worlds: A Case Series of Adenosquamous Carcinoma of the Esophagus.

Khaled H Husain, Rachael Hagen, Bianca Thakkar, Norbert Promagan, Minh Thu T Nguyen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Khaled H HusainDepartment of Medicine, University of Connecticut, Farmington, CT.ORCID https://orcid.org/0009-0009-1919-8129
Rachael HagenDepartment of Medicine, University of Connecticut, Farmington, CT.
Bianca ThakkarDepartment of Medicine, University of Connecticut, Farmington, CT.
Norbert PromaganDepartment of Pathology, Hartford Hospital, Hartford, CT.
Minh Thu T NguyenDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Connecticut, Farmington, CT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal adenosquamous carcinoma (EASC) is a rare, aggressive malignancy with histologic features of both squamous cell carcinoma and adenocarcinoma. We report a case series of 2 patients with EASC. The first case involves a middle-aged woman with traditional risk factors, including a 46-pack-year smoking history, frequent alcohol use, and long-segment Barrett's esophagus, managed with neoadjuvant chemoradiation, esophagectomy with lymphadenectomy, and radiofrequency ablation. The second case involves a young man without traditional risk factors who presented with advanced disease. These cases highlight the diagnostic and therapeutic challenges of EASC and the need for comprehensive management and vigilant surveillance.

Indexed as

adenosquamous carcinomaBRCA2 mutationesophageal cancer

Identifiers

PMID42170170
PMCPMC13189588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.