ArticleCureus2026
IgG4-Related Retroperitoneal Fibrosis Presenting as Obstructive Acute Kidney Injury: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder with retroperitoneal fibrosis (RPF) representing a recognized manifestation. Ureteric encasement by fibroinflammatory tissue may result in obstructive uropathy and acute kidney injury (AKI). We report the case of a 46-year-old male who presented with bilateral flank pain and severe AKI. Cross-sectional imaging demonstrated a retroperitoneal soft-tissue mass causing bilateral hydroureteronephrosis. Initial management with bilateral ureteric stent insertion resulted in marked improvement in renal function. Subsequent CT-guided biopsy revealed a fibroinflammatory spindle cell lesion consistent with IgG4-related RPF. The patient later re-presented with recurrent anuria and deterioration in renal function, raising concern for disease relapse. Rheumatology assessment confirmed IgG4-RD; however, initiation of definitive immunosuppressive therapy was deferred due to a concurrent urinary tract infection. Following resolution of infection, immunosuppressive treatment was commenced. This case underscores the diagnostic and therapeutic challenges of IgG4-related RPF and highlights the importance of multidisciplinary management, particularly in differentiating disease activity from superimposed infection.
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