ArticleRSC advances2026
Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chemically modifying the backbone, sugar, or nucleobase moieties of nucleic acids greatly expands their functional repertoire. Nucleobase modifications have received particular attention for their proven ability to generate a greater diversity of intra- and intermolecular interactions. This broader interaction landscape has facilitated advances in the identification of aptamers with high affinity to different target molecules, including proteins. As common practice, SELEX (Systematic Evolution of Ligands by EXponential enrichment) is used to select the best binders from a large pool of random oligonucleotides. However, the combinatorial space of SELEX is usually limited to
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