Evidence map›Paper›PMID 42170015›Full record

ArticleChina CDC weekly2026

A Randomized, Double-Blind, Positive-Controlled Phase III Clinical Trial of an Anti-Rabies Monoclonal Antibody for Category III Rabies Exposure in Individuals Under 18 Years - China, 2021-2023.

Jingyu Li, Yu Zhao, Yan Zheng, Xuexia Zhang, Ya Jiang, Jiangshu Guo, Wenmei Bao, Yinfeng Ma, Yaoyuan Zhang, Shuyuan Yin and 3 more

Abstract read
In one paragraph

Article in China CDC weekly, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jingyu Li *Yunnan Provincial Center for Disease Control and Prevention, Kunming City, Yunnan Province, China.
Yu Zhao *State Key Laboratory of Antibody Research and Development, North China Pharmaceutical Company (NCPC) New Drug Research and Development Co., Ltd., Shijiazhuang City, Hebei Province, China.
Yan ZhengYunnan Provincial Center for Disease Control and Prevention, Kunming City, Yunnan Province, China.
Xuexia ZhangState Key Laboratory of Antibody Research and Development, North China Pharmaceutical Company (NCPC) New Drug Research and Development Co., Ltd., Shijiazhuang City, Hebei Province, China.
Ya JiangMile Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture, Yunnan Province, China.
Jiangshu GuoGejiu Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture, Yunnan Province, China.
Wenmei BaoKaiyuan Center for Disease Control and Prevention, Honghe Hani and Yi Autonomous Prefecture, Yunnan Province, China.
Yinfeng MaQiubei County Center for Disease Control and Prevention, Wenshan Zhuang and Miao Autonomous Prefecture, Yunnan Province, China.
Yaoyuan ZhangState Key Laboratory of Antibody Research and Development, North China Pharmaceutical Company (NCPC) New Drug Research and Development Co., Ltd., Shijiazhuang City, Hebei Province, China.
Shuyuan YinState Key Laboratory of Antibody Research and Development, North China Pharmaceutical Company (NCPC) New Drug Research and Development Co., Ltd., Shijiazhuang City, Hebei Province, China.
Yirui MaState Key Laboratory of Antibody Research and Development, North China Pharmaceutical Company (NCPC) New Drug Research and Development Co., Ltd., Shijiazhuang City, Hebei Province, China.
Lijie WangState Key Laboratory of Antibody Research and Development, North China Pharmaceutical Company (NCPC) New Drug Research and Development Co., Ltd., Shijiazhuang City, Hebei Province, China.
Xiaoqiang LiuYunnan Provincial Center for Disease Control and Prevention, Kunming City, Yunnan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

What is already known about this topic?: Anti-rabies monoclonal antibodies in combination with rabies vaccines have demonstrated safety and immunogenicity as alternatives to rabies immunoglobulins for category III post-exposure prophylaxis in adults. What is added by this report?: This randomized, double-blind, active-control phase III trial demonstrates the immunogenicity and safety of an anti-rabies monoclonal antibodies in individuals aged <18 years with category III rabies exposure. What are the implications for public health practice?: These findings support the use of recombinant human monoclonal antibodies in pediatric populations and their potential role as alternative passive immunization options for category III rabies post-exposure prophylaxis in individuals aged <18 years.

Indexed as

anti-rabies virus monoclonal antibodyOrmutivimabrabiesrabies virus

Identifiers

PMID42170015
PMCPMC13187673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.