Evidence map›Paper›PMID 42170004›Full record

ReviewJournal of human immunity2026

How I Treat: Chronic granulomatous disease.

Jennifer W Leiding, Leah H Pettiford, Christopher C Chang, Aimee M Dassner, Mary C Dinauer, Benjamin R Hanisch, Nada Harik, Elizabeth D Hicks, Harry L Malech, Felicia B Morton and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jennifer W LeidingDivision of Allergy & Immunology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-7573-9390
Leah H PettifordDivision of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0009-0005-7298-4066
Christopher C ChangDivision of Immunology, Allergy and Pediatric Rheumatology, Joe DiMaggio Children's Hospital, Memorial Healthcare System, Hollywood, FL, USA.ORCID https://orcid.org/0000-0002-4397-5217
Aimee M DassnerDivision of Infectious Diseases, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0009-0005-4874-8303
Mary C DinauerDivision of Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0002-7796-2908
Benjamin R HanischDivision of Infectious Diseases, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0003-3387-9093
Nada HarikDivision of Infectious Diseases, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0003-0445-8652
Elizabeth D HicksDivision of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0002-0832-1648
Harry L MalechLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-5874-5775
Felicia B MortonCGD Association of America, West Palm Beach, FL, USA.ORCID https://orcid.org/0009-0002-8441-2768
Peter E NewburgerDivision of Pediatric Hematology-Oncology, UMass Chan Medical School, Worcester, MA, USA.ORCID https://orcid.org/0000-0002-8615-673X
Kathleen E SullivanDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-3577-9021
Brant R WardDivision of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0001-8056-6466
Michael D KellerDivision of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0001-8323-3085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic granulomatous disease (CGD) is a rare inborn error of immunity with both high risk of invasive bacterial and fungal infections as well as inflammatory complications. Though diagnostic testing via the dihydrorhodamine assay is widely available, disease recognition can be challenging due to the broad range of initial clinical presentations. Preventative antimicrobial therapy is the backbone of management, while treatment of inflammatory disease remains a challenge. Definitive therapy via hematopoietic stem cell transplantation is increasingly favored for resolution of long-term disease risks, while gene therapy remains a promising but investigational treatment. Here, we present our consensus approach to diagnosis and management of CGD.

Identifiers

PMID42170004
PMCPMC13177424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.