ReviewJournal of human immunity2026
From variants to answers: The evolution of genetic counseling in IEI.
Review in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Australasian Society of Clinical Immunology and Allergy consensus statement on IEI molecular diagnosis.Journal of human immunity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inborn errors of immunity (IEIs) comprise >500 rare congenital disorders of the immune system, characterized by susceptibility to infection and immune dysregulation. Genetic testing advances have improved the comprehension of their molecular mechanisms and informed personalized therapeutic strategies. Nevertheless, the interpretation of variants and their clinical relevance remain challenging. Together with the technological limitations of next-generation sequencing and emerging methods, this highlights the need for standardized, reproducible approaches. The decision-making needs to incorporate effective genetic counseling, ethical and communicative considerations, and collaboration between clinicians, geneticists, and bioinformaticians. Ensuring equitable access to advanced genetic diagnostics is crucial to support accurate diagnoses, guide clinical management, and inform family planning. All this together highlights the need to combine clinical expertise and genetic research into an interdisciplinary collaboration, enabling individualized treatment and improved outcomes for individuals with IEIs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.