ArticleJournal of gastrointestinal oncology2026
Identification of immunogenic cell death-related prognostic genes in gastric cancer.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immunogenic cell death (ICD) is an important regulatory form of cell death, which can trigger anti-tumor immune responses and plays a crucial role in the development of cancer. Gastric cancer (GC) is a highly malignant tumor with poor prognosis. Currently, there is still a need to explore effective prognostic markers for clinical risk stratification. Therefore, this study aims to identify key prognostic genes related to ICD and construct a novel prognostic signature for the prognosis assessment of GC. Methods: Single cell RNA sequencing (scRNA-seq) analysis was performed to identify distinct cell subpopulations and key cell types. Various analytical approaches, including differential expression analysis, weighted gene co-expression network analysis (WGCNA), and least absolute shrinkage and selection operator (LASSO)-Cox analysis, were used to pinpoint prognostic genes in GC samples. A prognostic model was developed based on these genes to predict the survival outcomes of GC patients. Furthermore, a nomogram was created based on independent prognostic factors to estimate the survival probability for these patients. Results: A total of 10 distinct cell subpopulations were annotated, with CD8+ natural killer T-like (NKT-like) cells as key cells for GC. Through comprehensive analysis, five prognostic genes- Conclusions: We identified five ICD-related prognostic genes-
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