ArticleJournal of gastrointestinal oncology2026
Brain metastasis from KRAS wild-type pancreatic cancer and organoid correlates: a case report.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Daraxonrasib and the era of pan-RAS inhibition: mechanisms, clinical advances, and resistance landscapes.Experimental hematology & oncology · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Background: Although pancreatic cancer is an aggressive malignancy with a propensity for metastatic spread, brain metastases (BrMs) remain exceptionally rare (<1% incidence). Case Description: We present a case of BrMs in a 69-year-old pancreatic cancer patient. This patient initially presented with a history of chronic pancreatitis, abdominal and back pain, and significant weight loss. After the diagnostic biopsy confirmed pancreatic cancer, the patient was enrolled onto the PASS-01 clinical trial and was treated with standard of care chemotherapy before progressing and developing BrMs 10 months after cancer diagnosis. The BrMs were removed via craniotomy, and the patient also underwent radiation and chemotherapy before enrolling onto the MYTHIC clinical trial for PKMYT1 inhibitor, RP-6306. Successful generation of a BrM-derived organoid line enabled high-throughput drug screening, which recapitulated the patient's clinical resistance to standard therapies [gemcitabine/nab-paclitaxel, 5-fluorouracil (5-FU)], and showed sensitivity to afatinib, everolimus and RMC-6236. Conclusions: This case report demonstrates the importance of precision medicine to characterize patient tumor and identify actionable targets and potential therapies. Physicians should also be aware that
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