Evidence map›Paper›PMID 42169907›Full record

ArticleJournal of gastrointestinal oncology2026

Multi-institutional care is associated with improved survival in biliary tract cancer.

Trisha Lal, Jay Han, Natalie N Chakraborty, Kai Zhao, Amit Mahipal, Christopher Towe, John B Ammori, Richard S Hoehn

Abstract read
In one paragraph

Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Trisha LalDivision of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.ORCID https://orcid.org/0009-0000-5821-1159
Jay HanSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Natalie N ChakrabortyDivision of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.
Kai ZhaoSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Amit MahipalSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Christopher ToweCase Comprehensive Cancer Center, Cleveland, OH, USA.
John B AmmoriDivision of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.
Richard S HoehnDivision of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Biliary tract cancers (BTCs) often require coordinated, multi-institutional care (MC). While MC has been associated with worse outcomes in some cancers, its impact on BTC remains unknown. This study aimed to examine predictors of MC and its association with survival after curative-intent resection for BTC. Methods: Using the National Cancer Database (2004-2022), we retrospectively identified adults undergoing curative-intent resection for stage I-III BTC. MC was defined as receiving treatment across multiple facilities. Multivariable logistic regression identified predictors of MC. Overall survival (OS) was assessed with Kaplan-Meier (KM) and Cox proportional-hazards models. Results: Among 13,250 patients, 2,824 (21.3%) received MC. Younger age, non-Hispanic White race, private insurance, higher socioeconomic status, and greater travel distance independently predicted MC (all P<0.001). Treatment at community cancer programs was the strongest predictor [odds ratio (OR) 2.25, 95% confidence interval (CI): 1.79-2.83]. MC was associated with improved OS compared with single-facility care [hazard ratio (HR) 0.85, 95% CI: 0.80-0.89]. In stratified analyses, patients treated at multiple facilities, regardless of surgical volume, had the most favorable survival, whereas single low-volume centers had the poorest outcomes (log-rank P<0.0001). Conclusions: MC was associated with improved survival after resection in BTC. These findings support a coordinated model centralizing complex surgery while delivering other treatments locally. Implementation should prioritize equitable access through streamlined referral pathways and shared perioperative protocols.

Indexed as

Biliary tract cancer (BTC)multi-institutional care (MC)surgical outcomessurgical volume

Identifiers

PMID42169907
PMCPMC13187998

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.