ArticleJournal of gastrointestinal oncology2026
Prognostic impact of low absolute skeletal muscle mass 6 months after gastrectomy for gastric cancer: a retrospective cohort study.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Preoperative low skeletal muscle mass (SMM) is a well-established predictor of poor short- and long-term outcomes in gastric cancer. However, the prognostic significance of absolute SMM at specific postoperative time points remains unclear. This study aimed to evaluate the impact of absolute SMM measured 6 months after curative gastrectomy on overall survival (OS) and disease-free survival (DFS). Methods: We retrospectively analyzed 151 patients who underwent curative gastrectomy for gastric cancer at a single institution between January 2015 and December 2021. The psoas muscle index (PMI, cm Results: At 6 months postoperatively, 115 patients (76%) were classified into the L group, and 36 patients (24%) into the N group. The L group had significantly shorter OS than the N group (P=0.006), while DFS did not differ significantly between groups (P=0.43). No significant differences in OS or DFS were observed based on ΔPMI. Multivariate analysis identified low absolute SMM at 6 months [hazard ratio (HR) =4.660; 95% confidence interval (CI), 1.111-19.550; P=0.03] and tumor stage (stage II/III Conclusions: Low absolute SMM at 6 months after gastrectomy independently predicted poor OS, whereas ΔPMI was not independently associated with OS. Measuring absolute SMM at this mid-term postoperative stage may serve as a simple, clinically meaningful marker for long-term risk stratification after gastrectomy.
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