ArticleJournal of gastrointestinal oncology2026
A case report of gastroesophageal adenocarcinoma with yolk sac tumor differentiation in a pregnant patient.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gastroesophageal adenocarcinomas with yolk sac tumor (YST) differentiation is an exceptionally rare and aggressive malignancy with only a limited number of cases described in the literature. YSTs are typically gonadal in origin with only a small percentage presenting in extragonadal sites. Somatic tumors, such as gastroesophageal adenocarcinoma, that have YST differentiation remain poorly understood. To our knowledge, such a presentation in the context of pregnancy has not been previously documented, making this case uniquely challenging in terms of diagnosis, management, and prognosis. Case Description: We report the case of a 22-year-old gravida 1 para 0 female at 29 weeks gestation who presented with gastrointestinal bleeding and right upper quadrant pain. Imaging revealed hepatic, pancreatic, and multiple pulmonary metastases. The liver biopsy initially suggested high-grade neuroendocrine carcinoma, but subsequent pathology review confirmed adenocarcinoma with YST differentiation originating at the gastroesophageal junction. The patient underwent emergent Cesarean section followed by sequential cytotoxic anticancer treatments with short lived responses during and after each regimen. The patient died 18 months after initial presentation. Conclusions: This case underscores the diagnostic complexity and therapeutic challenges of gastroesophageal adenocarcinomas with YST differentiation, especially in young patients. It highlights the importance of expert specialized pathology review, multidisciplinary care, and further research into effective treatment strategies for this rare entity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.